کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425656 | 1295885 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acetylcholine release is elicited in the visual cortex, but not in the prefrontal cortex, by patterned visual stimulation: A dual in vivo microdialysis study with functional correlates in the rat brain
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کلمات کلیدی
PBSPFCVDBHDBACh - آهAcetylcholine - استیل کولینhorizontal limb of the diagonal band of Broca - اندام افقی از گروه مورب Brocavertical limb of the diagonal band of broca - اندام عمودی از گروه مورب Brocaphosphate buffer - بافر فسفاتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceretrograde tracing - ردیابی عقب ماندهFast Blue - سریع آبیCholinergic system - سیستم Cholinergicprefrontal cortex - قشر prefrontalprimary visual cortex - قشر بصری اولیهsubstantia innominata - ماده تعیین شدهbasal forebrain - پیشانی پایهChAT - چتVision - چشم اندازcholine acetyltransferase - کولین استیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
By its projections to the primary visual and the prefrontal cortices, the basal forebrain cholinergic system is involved in cognitive processing of sensory stimuli. It has been suggested that visual stimulus-induced cholinergic activation of the visual cortex may exert a permissive role on thalamocortical inputs. However, it is not known if visual stimulation elicits cholinergic activation of high-order brain areas in the absence of attentional need. In the present study, we measured the effects of patterned visual stimulation (horizontal grating) on the release of acetylcholine with dual-probe in vivo microdialysis in the visual and the prefrontal cortices of anesthetized rats. We also used retrograde tracing to determine the anatomical relationships of cholinergic neurons with neurons of the visual system and the prefrontal cortex. Finally, we evaluated a functional correlate of this stimulation, namely c-fos immunolabeling. Patterned visual stimulation elicited significant increases in acetylcholine release in the visual cortex, accompanied by an increased number of c-fos immunoreactive neurons in this brain area. In contrast, in the prefrontal cortex, neither the level of acetylcholine release nor the number of c-fos immunoreactive neurons was significantly changed because of the stimulation. Cholinergic basal forebrain neurons projecting to the visual or the prefrontal cortices were both localized within the horizontal limb of the diagonal band of Broca but were not immunoreactive for c-fos during visual stimulation. No parts of the visual system were found to directly project to these basal forebrain neurons. These results suggest the differential involvement of cholinergic projections in the integration of sensory stimuli, depending on the level of activity of the targeted cortical area.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 132, Issue 2, 2005, Pages 501-510
Journal: Neuroscience - Volume 132, Issue 2, 2005, Pages 501-510
نویسندگان
F. Laplante, Y. Morin, R. Quirion, E. Vaucher,