کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425733 | 1295889 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thalamic nucleus submedius receives GABAergic projection from thalamic reticular nucleus in the rat
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کلمات کلیدی
VLO5-HTnucleus submediusDABPBSVPLNGSVPM5-hydroxytryptamine 1APAG5-HT1Afluoro-goldBDAABC3,3-diaminobenzidine tetrahydrochloride - 3،3-دیامینبنزیدین تتراهیدرکلراید5-hydroxytryptamine (serotonin) - 5-hydroxytryptamine (سروتونین)Immunohistochemistry - ایمونوهیستوشیمیphosphate buffer - بافر فسفاتbiotinylated dextranamine - بیاتینیلد دکسترانامینMidbrain periaqueductal gray - خاکستری پرایاکتیو Midbrainnormal goat serum - سرم طبیعی بزVentrolateral orbital cortex - قشر مغزی Ventrolateralventrobasal complex - مجتمع ventrobasalavidin–biotin–peroxidase complex - مجتمع آویدین-بیوتین پراکسیدازPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریRat - موش صحراییThalamic reticular nucleus - هسته reticular توالیومThalamic nucleus submedius - هسته تالاموس submediusreticular thalamic nucleus - هسته تالامیک رتیکالventral posterolateral thalamic nucleus - هسته تالامیک پست سلولی شکمیlateral geniculate nucleus - هسته ژنیکول جانبی جانبیGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Thalamic nucleus submedius receives GABAergic projection from thalamic reticular nucleus in the rat Thalamic nucleus submedius receives GABAergic projection from thalamic reticular nucleus in the rat](/preview/png/9425733.png)
چکیده انگلیسی
GABAergic projection from thalamic reticular nucleus to thalamic nucleus submedius in the medial thalamus of the rat was studied by using immunohistochemistry for GABA, retrograde labeling with Fluoro-Gold combined with immunohistochemistry for GABA, and anterograde labeling with biotinylated dextranamine. Immunohistochemistry displayed that only GABA immunoreactive terminals were observed in the thalamic nucleus submedius, while GABA immunoreactive neuronal cell bodies were located in the thalamic reticular nucleus and lateral geniculate nucleus. Injection of Fluoro-Gold into the thalamic nucleus submedius resulted in massive retrogradely labeled neuronal cell bodies in the rostroventral portion of the ipsilateral thalamic reticular nucleus and a few in the contralateral thalamic reticular nucleus, and most of these cell bodies showed GABA immunopositive staining. Many biotinylated dextranamine anterogradely labeled fibers and terminals in the thalamic nucleus submedius were observed after injection of biotinylated dextranamine into the thalamic reticular nucleus. The present results provide a morphological evidence for a hypothesis that a disinhibitory effect on output neurons elicited by opioid or 5-hydroxytryptamine inhibiting a GABAergic terminal in the thalamic nucleus submedius may lead to activation of the descending inhibitory system and depression of the nociceptive inputs at the spinal cord level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 134, Issue 2, 2005, Pages 515-523
Journal: Neuroscience - Volume 134, Issue 2, 2005, Pages 515-523
نویسندگان
J. Wang, F.-Q. Huo, Y.-Q. Li, T. Chen, F. Han, J.-S. Tang,