کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425743 | 1295889 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Post-exposure treatment attenuates noise-induced hearing loss
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کلمات کلیدی
PBSl-NACJnk4-HNE4-hydroxynonenalc-Jun-N-terminal kinaseOHCdB SPLNIHLRNSABRROS - ROSAntioxidants - آنتی اکسیدانnoise-induced hearing loss - افت شنوایی ناشی از سر و صداIHC - ایمونوهیستوشیمیFree radicals - رادیکال آزادHair cells - سلول های مویPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریnitrotyrosine - نیتروتیروستینNitric oxide - نیتریک اکسیدauditory brainstem response - پاسخ شنوایی مغزInner ear - گوش داخلیreactive nitrogen species - گونه های واکنش پذیر نیتروژنReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Guinea-pigs were subjected to 4 kHz octave band noise at 120 decibels sound- pressure-level (dB SPL) for 5 hours and received treatment with ROS and RNS scavengers (salicylate and trolox) beginning 3 days prior, 1 hour, 1, 3, or 5 days after noise exposure. Auditory thresholds were assessed by sound-evoked auditory brainstem response at 4, 8, and 16 kHz, before and 10 days after noise exposure. Hair cell damage was analyzed by quantitative histology, and free radical activity was determined immunohistochemically via 4-hydroxynonenal and nitrotyrosine as markers of reactive oxygen species and reactive nitrogen species action. Delivered up to 3 days after noise exposure, salicylate and trolox significantly reduced auditory brainstem response deficits, reduced hair cell damage, and decreased reactive oxygen species and reactive nitrogen species formation. Earlier drug treatment was more effective than later treatment. Our results detail a window of opportunity for rescue from noise trauma, and provide evidence for both morphological and functional protection by delayed pharmacological intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 134, Issue 2, 2005, Pages 633-642
Journal: Neuroscience - Volume 134, Issue 2, 2005, Pages 633-642
نویسندگان
D. Yamashita, H.-Y. Jiang, C.G. Le Prell, J. Schacht, J.M. Miller,