Keywords: Dopamine; Lipopolysaccharide; Acute liver injury; Apoptosis; c-jun-N-terminal kinase;
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Keywords: Immune Response; Kras; PDAC; Tumorigenesis; ADM; Acinar-ductal metaplasia; AKT; protein kinase B; ERK; extracellular signal-regulated kinase; ESC; embryonic stem cell; GFP; green fluorescent protein; IL; interleukin; IL17R; interleukin 17 receptor; JNK;
Keywords: MNCs; multinucleated cells; TRAP; tartrate-resistant acid phosphatase; RANKL; receptor activator of nuclear factor-κB ligand; M-CSF; macrophage colony stimulating factor; OPG; osteoprotegerin; c-fms; colony-stimulating factor-1 receptor; ERK; extracellul
Keywords: ALA; 5-aminolevulinic acid; Akt; protein kinase-B; 8-Br-cGMP; 8-bromoguanosine 3â²,5â²-cyclic monophosphate; Ho; Hoechst-33258; iNOS; inducible nitric oxide synthase; IκB; inhibitor of NF-κB; Iκκ; IκB kinase; JNK; c-Jun-N-terminal kinase; 1400W; N-
Keywords: PSPC; purple sweet potato color; HFD; high-fat diet; NAFLD; nonalcoholic fatty liver disease; T2D; type 2 diabetes; ER stress; endoplasmic reticulum stress; TG; triglyceride; TC; total cholesterol; ALT; alanine aminotransferase; AST; aspartate aminotransf
Qingchangligan formula alleviates acute liver injury by attenuating extracellular histone-associated inflammation
Keywords: ACLF; acute-on-chronic liver failure; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ConA; concanavalin A; ERK; extracellular regulated protein kinase; H & E; hematoxylin and eosin; IFN-γ; interferon-γ; IL-1β; interleukin-1β; IL-6; in
Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis
Keywords: ADAMT; aggrecanase disintegrin and metalloproteinase with thrombospondin Motifs; AGE; advanced glycation end products; Akt; protein kinase B; AP; activator protein; CRP; C-reactive protein; ECM; extra cellular matrix; DAMP; damaged associated molecular pa
Systemic administration of scAAV9-IGF1 extends survival in SOD1G93A ALS mice via inhibiting p38 MAPK and the JNK-mediated apoptosis pathway
Keywords: Amyotrophic lateral sclerosis; Transgenic SOD1-G93A mice; Insulin-like growth factor 1; Apoptosis; c-Jun-N-terminal kinase; p38 mitogen-activated protein kinase;
Mapping Txnip: Key connexions in progression of diabetic nephropathy
Keywords: ARRB; arrestin beta; ARRDC; arrestin domain containing protein; ASK-1; apoptosis signal-regulating kinase-1; Cys; cysteine; ECM; extracellular matrix; FOXO; forkhead box protein; Gly; glycine; IL-1β; interleukin-1 β; JNK; c-Jun-N-terminal kinase; MAPK;
Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice
Keywords: 3-NT; 3-nitro-tyrosine; ALI; acute liver injury; ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; CAT; catalase; Cl-Cas-3; cleavage Caspase-3; CYP2E1; cytochrome P450 2E1; ERK1/2; extracellular signal-regulated kinase 1
Histidine-alleviated hepatocellular death in response to 4-hydroxynonenal contributes to the protection against high-fat diet-induced liver injury
Keywords: 4-HNE; 4-hydroxynonenal; ALT; alanine aminotransferase; AML-12 hepatocyte; alpha mouse liver-12 hepatocyte; AMPK; AMP-activated protein kinase; DCFH-DA; 2,7-dichloro-dihydro-fluorescein diacetate; DMEM; Dulbecco's Modified Eagle Medium; DMEM/F-12; Dulb
Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion
Keywords: AA; Antimycin A; ALL; Allopurinol; ASK1; Apoptosis-signaling kinase 1; DCFH2-DA; 5-(6)-carboxy-2â², 7â²-dichlorodihydrofluorescein diacetate; DPI; Diphenyleneiodonium; ERK; Extracellular signal regulated kinase; H2O2; Hydrogen peroxide; JNK; c-Jun-N-ter
Exogenous hydrogen sulfide eliminates spatial memory retrieval impairment and hippocampal CA1 LTD enhancement caused by acute stress via promoting glutamate uptake
Keywords: H2S; hydrogen sulfide; MWM; Morris water maze; LTD; long-term depression; fEPSP; field excitatory postsynaptic potential; LFS; low-frequency stimulation; tPDC; l-trans-pyrrolidine-2,4-dicarboxylic; DTT; dithiothreitol; DTNB; 5,5â²-dithio-bis(2-nitrobenzo
Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells
Keywords: AO; acridine orange; ATP; adenosine triphosphate; CaMK; calcium-calmodulin kinase; EGTA; ethylenebis(oxyethylenenitrilo)tetraacetic acid; IM-54; 2-(1H-Indol-3-yl)-3-pentylamino-maleimide; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazo
The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events
Keywords: CCK; COOH-terminal octapeptide of cholecystokinin; TPA; 12-O-tetradecanoylphorbol-13-acetate; PAK; p21-activated kinases; SFK; Src family of kinases; PKC; protein kinase C; PYK2; proline-rich tyrosine kinase 2; FAK; focal adhesion kinase; SHC; Src homolog
2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells
Keywords: CAT; catalase; DAF-FM; 4-amino-5-methylamino-2â²,7â²-mifluorofluorescein; DCFH2-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DHE; dihydroethidium; DMSO; dimethyl sulfoxide; DPI; diphenyleneiodonium; ERK; extracellular signal regulated kinase; FLR
Research ArticleMetformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice
Keywords: APAP; acetaminophen; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CAR; constitutive androstane receptor; CYP450; cytochrome P450; GSH; glutathione; Gadd45β; growth arrest and DNA damage-inducible 45 beta; JNK; c-Jun-N-terminal kinase;
Gentamicin alters Akt-expression and its activation in the guinea pig cochlea
Keywords: ABR; auditory brainstem response; AU; arbitrary units; JNK; c-Jun-N-terminal kinase; PI3K; phosphatidylinositol-3 kinase; ROS; reactive oxygen species; SD; standard deviation; hearing loss; immunohistochemistry; inner ear; organ of Corti; cytoprotection;
Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice
Keywords: Mouse Model; Stress Signaling; Obesity; Inflammation; CDAA; choline-deficient amino acid defined; CHOP; CCAAT/enhancer-binding protein homologous protein; CSAA; choline-supplemented l-amino acid; ER; endosplasmic reticulum; FFD; fast-food diet; HSC; hepat
Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning
Keywords: Acetaminophen hepatotoxicity; Allopurinol; Oxypurinol; Aldehyde oxidase; c-Jun-N-terminal kinase; Metallothionein;
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes
Keywords: Drug-induced liver injury; Acetaminophen protein adducts; Oncotic necrosis; c-Jun-N-terminal kinase; Mitochondrial dysfunction
Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals
Keywords: 4-HNE; 4-hydroxynonenal; 8OH-dG; 8-hydroxy-2â²deoxyguanosine; AMPK; cyclic-AMP-activated protein kinase; ARE; antioxidant response element; ATF; activating transcription factor; B[a]P; Benzo[a]pyrene; Bach1; broad-complex, tramtrack and bric a brac; CBP;
Card9 Mediates Intestinal Epithelial Cell Restitution, T-Helper 17 Responses, and Control of Bacterial Infection in Mice
Keywords: Colitis; ILC; Inflammatory Response; Mouse Model; AMP; antimicrobial peptide; ASCA; anti-Saccharomyces cerevisiae antibody; CARD9; caspase recruitment domain 9; Ccl20; chemokine (C-C motif) ligand 20; CFU; colony forming unit; DSS; dextran sulfate sodiu
Transglutaminase-2 induces N-cadherin expression in TGF-β1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation
Keywords: TGF-β1-induced epithelial mesenchymal transition; N-cadherin expression; Transglutaminase-2; A549 orthotopic model; C-Jun-N-terminal kinase; PP2A
Transforming Growth Factor-β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1
Keywords: Liver Cancer; Mouse Model; Signal Transduction; Oncogene; ALT; alanine aminotransferase; CTGF; connective tissue growth factor; DEN; n-nitrosodiethylamine; GFP; green fluorescent protein; HCC; hepatocellular carcinoma; IKK; IκB kinase; IL; interleukin; J
Healing the diabetic heart: Does myocardial preconditioning work?
Keywords: I/R; Ischemia-reperfusion; TNF-α; Tumor necrosis factor-alpha; IPC; Ischemic preconditioning; FWOP; First window of protection; SWOP; Second window of protection; TWOP; Third window of protection; eNOS; Endothelial nitric oxide synthase; NO; Nitric oxi
Research ArticleNilotinib protects the murine liver from ischemia/reperfusion injury
Keywords: MAPK; mitogen-activated protein kinase; JNK; c-Jun-N-terminal kinase; I/R; ischemia/reperfusion; ALT; alanine aminotransferase; NPC; non-parenchymal cell; MAP2K; MAPK kinase; MAPKAPK2; MAPK activating protein kinase 2; PDGFR; platelet-derived growth facto
Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury
Keywords: ROS; reactive oxygen species; MAPK; mitogen-activated protein kinase; PAECs; porcine aorta endothelial cells; GSH; glutathione; NAC; N-acetylcysteine; BSO; l-buthionine-(S,R)-sulfoximine; DPPP; diphenyl-1-pyrenylphosphine; WST-8; 2-(2-methoxy-4-nitropheny
How well do aliskiren's purported mechanisms track its effects on cardiovascular and renal disorders?
Keywords: ACE; angiotensin converting enzyme; Ang-II; angiotensin-II; Aog; angiotensinogen; ARB; Ang-II type 1 (AT1) receptor blocker; eNOS; endothelial nitric oxide synthase; HCTZ; hydrochlorothiazide; HRP; handle region peptide; JNK; c-Jun-N-terminal kinase; MAPK
Olmesartan attenuates the development of heart failure after experimental autoimmune myocarditis in rats through the modulation of ANG 1-7 mas receptor
Keywords: ACE-2; angiotensin converting enzyme-2; ANG (1-7); angiotensin-(1-7); ANG-II; angiotensin-II; ARBs; angiotensin receptor blockers; AT1R; angiotensin-II type 1 receptor; AT2R; angiotensin-II type 2 receptor; DHE; dihydroethidium; EAM; experimental autoim
Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice
Keywords: Mouse Model; Immune Response; Bone Marrow-Derived Macrophages; Myofibroblast; aHSCs; activated HSCs; α-SMA; α-smooth muscle actin; BDL; bile duct ligation; BM; bone marrow; CCl4; carbon tetrachloride; Col-GFP mice; collagen-α1(I)-GFP mice; EC; endothel
Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis
Keywords: 7α-OH; 7α-hydroxycholesterol; 7-K; 7-ketocholesterol; 9-ONC; 9-oxononanoyl cholesterol; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; α-EPOX; 5α,6α-epoxycholesterol; AP-1; activator protein-1; ARE; antioxidant-responsive element; ATF; activating trans
Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice
Keywords: AMPKα; AMP-activated protein kinase; GRP78 (also known as Bip); glucose regulator protein 78; CHOP; C/EBP homologous protein; eIF2α; eukaryotic initiation factor 2α; ELISA; enzyme-linked immunosorbent assay; ER; endoplasmic reticulum; ERK1/2; extracell
Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway
Keywords: ERK; extracellular signal-regulated kinase; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MEK; MAPK-ERK kinase; NOx; nitric oxide metabolite; TNF-α; tumor necrosis factor-alpha; ROS; reactive oxygen species; TLR; Toll-like receptor; Ï
Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2)
Keywords: AP-1; activator protein-1; CCL2; chemokine (C-C motif) ligand 2; c-Jun DN; c-Jun dominant-negative construct; EGTA; ethylene glycol tetraacetic acid; FAM3B; family with sequence similarity 3, member B; MAPK; mitogen-activated protein kinase; MCP-1; mono
Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells
Keywords: AD; Alzheimer's disease; ANOVA; analysis of variance; AP-1; activator protein-1; DCDHF; 5 (or 6)-carboxy-2â²,7â²-dichlorohydrofluorescein diacetate; DCF; 5-(and-6)-carboxy-2â²,7â²-dichlorofluorescein acid; DMEM; Dulbecco's modified Eagle medium; DTT;
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity
Keywords: Acetaminophen; Manganese-SOD; Oxidative stress; c-jun-N-terminal kinase; Apoptosis-inducing factor; Bax
Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3
Keywords: Nuclear receptors; Hepatocellular carcinoma; Cell cycle; Liver hyperplasia; AP-1; activating protein-1; PH; partial hepatectomy; JNK; c-jun-N-terminal kinase; HCC; hepatocellular carcinoma; PPAR-α; peroxisome proliferator-activated receptor-alpha; TCPOBO
LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-γ-independent manner by a JNK signaling pathway in primary murine microglia
Keywords: Neuroinflammation; Indoleamine 2,3-dioxygenase; Lipopolysaccharide; c-Jun-N-terminal kinase; Primary microglia
The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition
Keywords: c-Jun-N-terminal kinase; MAP kinase; Astrocytes; Spinal cord; Contralateral pain; Inflammation; Tactile allodynia;
Paired Immunoglobulin-Like Receptor B (PIR-B) Negatively Regulates Macrophage Activation in Experimental Colitis
Keywords: Inhibitory Receptors; Macrophages; IBD; DSS; dextran sodium sulfate; eGFP; enhanced green fluorescent protein; ERK; extracellular signal-regulated kinase; Ig; immunoglobulin; IL; interleukin; ILT; immunoglobulin-like transcript; ITIM; immunoreceptor tyr
JNK inhibition and inflammation after cerebral ischemia
Keywords: c-Jun-N-terminal kinase; Microglia; Neuroprotection; Inflammation; Middle cerebral artery occlusion; Oxygen and glucose deprivation
Adiponectin Modulates C-Jun N-Terminal Kinase and Mammalian Target of Rapamycin and Inhibits Hepatocellular Carcinoma
Keywords: Hepatocellular Carcinoma; Adiponectin; TSC2; mTOR; AMPK; adenosine monophosphateâactivated protein kinase; BMI; body mass index; HCC; hepatocellular carcinoma; JNK; c-Jun-N-terminal kinase; mTOR; mammalian target of rapamycin; TMA; tissue microarray; TS
Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease
Keywords: p38α; Colitis; Knockout Mice; BrdU; bromodeoxyuridine; DBZ; dibenzazepine; DSS; dextran sodium sulfate; IBD; inflammatory bowel disease; IL; interleukin; JNK; c-Jun-N-terminal kinase; NF-κB; nuclear factor κB; PAS; periodic acid-Schiff; PCR; polymera
Activation of c-Jun-N-terminal kinase in a rat model of intracerebral hemorrhage: The role of iron
Keywords: ATPase; adenosine triphosphatase; CSF; cerebrospinal fluid; DFX; deferoxamine; ECL; enhanced chemiluminescence; FDA; food and drug administration; holo-Tf; holo-transferrin; ICH; intracerebral hemorrhage; IgG; immunoglobulin G; i.p.; intraperitoneal injec
Activation of cell death pathways in the inner ear of the aging CBA/J mouse
Keywords: ABR; auditory brain stem evoked response; Endo G; endonuclease G; JNK; c-Jun-N-terminal kinase; MAPK; mitogen-activated protein kinases; PBS; phosphate-buffered saline; PI; Propidium iodide; ROS; reactive oxygen species; SAPK; stress-activated protein kin
Preconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk
Keywords: CREB; cyclic adenosine monophosphate response element binding protein; ERK1/2; extracellular signal-regulated kinase 1/2; JNK; c-Jun-N-terminal kinase; NMDA; N-methyl-d-aspartate; MAPK; mitogen-activated protein kinases; TUNEL; terminal deoxynucleotidyl t
SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes
Keywords: Human hepatocyte; p38 MAPK kinase; Extracellular-regulated kinase ERK; c-Jun-N-terminal kinase; SB203580; Cross-talk
CD95 Ligand Is a Proliferative and Antiapoptotic Signal in Quiescent Hepatic Stellate Cells
Keywords: BrdU; bromodeoxyuridine; CD95L; CD95 ligand; CHX; cycloheximide; DISC; death-inducing signaling complex; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Erk; extracellular signal-regulated kinase; HSC; hepatic stellate cell; JNK; c
Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells
Keywords: AGEs; advanced glycation end products; AMPK; AMP-activated kinase; BSA; bovine serum albumin; DCFH; 2â²,7â²-dichlorofluorescin diacetate; IMS; immortalized mouse Schwann cells; JNK; c-Jun-N-terminal kinase; MG; methylglyoxal; MTS; 3-(4,5- dimethylthiazo