Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury

► Endothelial cell dysfunction contributes to epirubicin-induced vascular injury. ► Epirubicin induces mitochondrial dysfunction and caspase-dependent apoptosis. ► Oxidative stress plays an important role in epirubicin-induced cell injury. ► Activation of p38 MAPK by oxidative stress is involved in endothelial cell injury.