Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2)

► PANDER is a peptide mainly synthesized and secreted by pancreatic β-cells. ► PANDER is involved in impairment of β-cell function under pathological conditions. ► MCP-1 induces PANDER expression at mRNA and protein levels in β-cells and islets. ► MCP-1 upregulates PANDER via Ca2+-ERK1/2-AP-1 and PKC-JNK-AP-1 signaling pathways. ► Our findings are helpful for investigating the pathophysiological roles of PANDER.