دانلود مقالات ISI درباره Pdx-1 + ترجمه فارسی

ژن درمانی و دیابت نوع 1

Gene therapy and type 1 diabetes mellitus

Keywords: T1DM; Type 1 diabetes mellitus; EDS; Search E-Resources; IGF1; insulin-like growth factor 1; NOD; non-obese diabetic; G6Pase; glucose-6-phosphatase; HGF; hepatocyte growth factor; SCID; severe combined immunodeficiency; BTC; betacellulin; Ngn3; Neurogenin

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

دگرگونی فیزیولوژیکی و اعوجاج متابولیسم مزمن هیپرگلیسمی منجر به اختلال عملکرد، عفونت، پیشرفت سرطان و سایر عواقب پاتوفیزیولوژیکی بدن می شود: به روز رسانی بر روی سمیت گلوکز

Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity

Keywords: AGEs; advanced glycation end-products; CAD; coronary artery disease; CRP C; reactive protein; CTGF; connective tissue growth factor; DAG; diacyl glycerol; DCM; diabetic cardio-myopathy; DFU; diabetic foot ulcer; eNOS; endothelial nitric oxide synthase; FO

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

مکانیسم پاسخ های کولنگیوسیت به آسیب

Mechanisms of cholangiocyte responses to injury

Keywords: AANAT; arylalkylamine N-acetyltransferase; AE2; Cl−/HCO3- anion exchanger 2; ANIT; α-naphthylisothiocyanate; BA; biliary atresia; BDL; bile duct ligation; cAMP; adenosine 3′,5′-cyclic monophosphate; CCA; cholangiocarcinoma; CCl4; carbon tetrachlo

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

برنامه های قرار گرفتن در معرض دگزامتازون قبل از زایمان، توسعه پانکراس و ترشح انسولین در موش صحرایی

Prenatal Dexamethasone Exposure Programs the Development of the Pancreas and the Secretion of Insulin in Rats

Keywords: diabetes mellitus; pancreas; PDX-1; prenatal dexamethasone exposure; programming;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

ارتباط سطوح بیان سلولهای پلوروپتیک / سلول های بنیادی با نتایج تمایز سلول های بنیادی مزانشیمی ژله وارتون به سلول های تولید کننده انسولین

Association of expression levels of pluripotency/stem cell markers with the differentiation outcome of Wharton's jelly mesenchymal stem cells into insulin producing cells

Keywords: Wharton's jelly; Mesenchymal stem cells; Diabetes mellitus; Insulin producing cells; Pluripotency/stem cell markers; CB-MSCs; Cord blood mesenchymal stem cells; CD; Cluster of differentiation; DM; Diabetes mellitus; DMEM; Dulbecco's modified Eagle medium;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

ماکروفاژهای ساکن ساکاروز: بازیکنان کلیدی در پاتوژنز دیابت نوع 2 و عوارض آن

Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications

Keywords: AGEs; advanced glycation end products; ATM; Adipose tissue macrophage; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor 1; CXCL; CXC chemokine l

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2016 سفارش ترجمه

بررسی اثربخشی و ریسک درمانهای ضد دیابتی: تجویز داروهای سنتی - تجدیدنظر مکانیکی برای درک نحوه عملکرد آنها

Efficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs-A mechanistic revisit to understand their mode of action

Keywords: GLUT; Glucose transporter; T1DM; Type-1 diabetes mellitus; T2DM; Type-2 diabetes mellitus; PKB/Akt; protein kinase B; GSK-3; glycogen synthase kinase-3; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1α; FOXO; forkhead box O; VLDL;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

تشخیص سلولهای اپیتلیال پانکراس گردش خون در بیماران مبتلا به ضایعات کیست تخمدان پانکراس

Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions

Keywords: Early Detection; IPMN; Circulating Tumor Cells; Pancreatic Cancer; CEC; circulating epithelial cell; DAPI; 4′,6-diamidino-2-phenylindole; GEDI; geometrically enhanced differential immunocapture; IPMN; intraductal papillary mucinous neoplasm; PDAC; pancr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

اثرات مکمل بیوتین در رژیم غذایی بر ترشح انسولین، بیان ژن جزیره، هوموتاز گلوکز و نسبت بتا-سلولی

Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion

Keywords: Foxa2; forkhead box A2; Hnf4α; hepatocyte nuclear factor 4α; Ncam1; neural cell adhesion molecule 1; PDX-1; pancreatic and duodenal homeobox 1; PPARα; peroxisome proliferator activated receptor alpha; PPARγ; peroxisome proliferator activated receptor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Sall2 knockdown exacerbates palmitic acid induced dysfunction and apoptosis of pancreatic NIT-1 beta cells

Keywords: PA; palmitic acid; NEFA; non-esterified fatty acid; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; shRNA; short hairpin RNA; CCK8; cell counting assay kit-8; Pdx-1; pancreatic and duodenal homeobox factor 1; MafA; V-maf musculoaponeuro

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link

Keywords: 3xTg; triple-transgenic; Aβ; β-amyloid; AD; Alzheimer's disease; ADAS-cog; Alzheimer's Disease Assessment Scale-cognitive subscale; Akt; protein kinase B; APP; amyloid precursor protein; CREB; cAMP-response element binding protein; DM; diabetes mell

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Liraglutide protects β-cell function by reversing histone modification of Pdx-1 proximal promoter in catch-up growth male rats

Keywords: Catch-up growth; Pdx-1; β-Cell function; Liraglutide; Histone modification;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

A novel synthetic human insulin super promoter for targeting PDX-1-expressing pancreatic cancer

Keywords: Synthetic human insulin super-promoter; PDX-1; Pancreatic ductal adenocarcinoma; Insulinoma; Gene therapy;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Metabolic roles of poly(ADP-ribose) polymerases

Keywords: ABCA1; ATP-binding cassette sub-family A member 1; ACACA; acetyl-CoA carboxylase alpha; ACBD3; acyl-CoA binding domain containing 3; ACLY; ATP citrate lyase; ADP; adenosine diphosphate; ADPR; ADP-ribose; AFLD; alcoholic fatty liver disease; AIF; apoptosis

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Low dose monoethyl phthalate (MEP) exposure triggers proliferation by activating PDX-1 at 1.1B4 human pancreatic beta cells

Keywords: Monoethyl phthalate; 1.1B4 cells; PDX-1; Diabetes; Mechanisms; Toxicity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2016 سفارش ترجمه

Liver, Pancreas and Biliary TractPDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: Perspectives in the diagnosis of pancreatic cancer

Keywords: EUS; FNA; Pancreatic cancer; PDX-1; Sensitivity; Specificity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development

Keywords: N-acetyl-l-cysteine (NAC) (PubChem CID: 12035); AKT; protein kinase B; AP-1; activator protein 1; CCL2; chemokine (C-C motif) ligand 2; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; FFA; free fatty acid; GLUT; gluc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Extra-nuclear activity of INSM1 transcription factor enhances insulin receptor signaling pathway and Nkx6.1 expression through RACK1 interaction

Keywords: INSM1; insulinoma-associated antigen-1; Ngn3; neurogenin 3; Pdx-1; pancreatic duodenal homeobox-1; MafA; musculoaponeurotic fibrosarcoma oncogene homolog A; ITF; islet transcription factor; NeuroD/β2; neurogenic differentiation factor D/beta 2; Pax6; pai

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels

Keywords: ABCA1; adenosine triphosphate-binding cassette transporter A1; ACACA; cetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOX2; acyl-CoA oxidase 2; ARTD2; ADP-ribosyl transferase diphtheria toxin-like 2; cyp51A1; cytochrome P450, family 51 subfamily A,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Expression, signaling and function of Egr transcription factors in pancreatic β-cells and insulin-responsive tissues

Keywords: Beta cell; Pancreas; Egr-1; Insulin; Pdx-1; Transcription

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells

Keywords: FFAR1; free fatty acid receptor 1; FFAs; free fatty acids; PIO; pioglitazone; PA; palmitic acid; ROS; reactive oxygen specific; PLCγ; Phospholipase C γ; ERK1/2; extracellular signal-regulated kinase 1/2; PPARγ; peroxisome proliferator activated recepto

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Oral administration of soybean peptide Vglycin normalizes fasting glucose and restores impaired pancreatic function in Type 2 diabetic Wistar rats

Keywords: Saline group; HFD/saline group; STZ group; HFD/STZ/saline group; Low group; HFD/STZ/Vglycin 40 μg/[g·d]; High group; HFD/STZ/Vglycin 80 μg/[g·d] group; Met group; HFD/STZ/Met; p-Akt; phosphorylated Akt; C-PARP; cleaved PARP; GSK3; Glycogen Synthase Ki

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticlePDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: Possible implications for sclerosing cholangitis

Keywords: PDX-1; Pancreatic Duodenal Homeobox-1; Hes-1; hairy and enhancer of split 1; NRC; normal rat cultured cholangiocytes; BDL; bile duct ligation; DDC; 3,5-diethoxycarbonyl-1,4-dihydrocollidine; PCNA; proliferating cell nuclear antigen; PSC; primary sclerosin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice

Keywords: GSIS; glucose-stimulated insulin secretion; PDX-1; pancreatic duodenal homeobox factor 1; SHP; small heterodimer partner; STZ; streptozotocin; Small heterodimer partner; Streptozotocin; Diabetes; Beta cell apoptosis; Insulin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The DPP-4 inhibitor MK0626 and exercise protect islet function in early pre-diabetic kkay mice

Keywords: DPP-4 inhibitor; Exercise; Pre-diabetes; Kkay mice; MafA; PDX-1; Proliferation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB

Keywords: Kaempferol; Palmitate; β-cells; Islets; cAMP; CREB; PDX-1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Mechanisms and techniques of reprogramming – Using PDX-1 homeobox protein as a novel treatment of insulin dependent diabetes mellitus

Keywords: PDX-1; Homeobox proteins; Diabetes; Reprogramming; β cells

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleMultipotent stem/progenitor cells in the human foetal biliary tree

Keywords: PDX-1; Pancreatic and duodenal homeobox 1; SOX17; SRY (sex determining region Y)-box 17; hHpSCs; human hepatic stem/progenitor cells; PBGs; peribiliary glands; hBTSCs; human biliary tree stem/progenitor cells; FBS; foetal bovine serum; KM; Kubota medium;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation

Keywords: EC; endothelial cells; VEGF-A; vascular endothelial growth factor-A; Ang1; angiopoietin-1; Ang2; angiopoietin-2; Dox; doxycycline; Rip-rtTA; rat insulin promoter-reverse tetracycline activator; Pdx-1; pancreatic-duodenal homeobox factor-1; GTT; glucose

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2)

Keywords: AP-1; activator protein-1; CCL2; chemokine (C-C motif) ligand 2; c-Jun DN; c-Jun dominant-negative construct; EGTA; ethylene glycol tetraacetic acid; FAM3B; family with sequence similarity 3, member B; MAPK; mitogen-activated protein kinase; MCP-1; mono

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin

Keywords: Adiponectin; Peptide; Beta-cell; Leptin; Cell viability; LPL; PDX-1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells

Keywords: ARNT; aryl hydrocarbon receptor nuclear translocator; ChREBP; carbohydrate responsive element-binding protein; ChIP; chromatin immunoprecipitation; ChoRE; carbohydrate-responsive element; FAS; fatty acid synthase; GcK; glucokinase; GFP; green fluorescent

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity

Keywords: BA; bile acids; BSA; bovine serum albumin; FGF; fibroblast growth factor; GSCN; guanidinium thiocyanate; FXR; farnesoid X receptor; GSIS; glucose-stimulated insulin secretion; IAPP; islet amyloid polypeptide; IPGTT; intraperitoneal glucose tolerance test;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Research ArticlePancreatic Duodenal Homeobox-1 de novo expression drives cholangiocyte neuroendocrine-like transdifferentiation

Keywords: PDX-1; Pancreatic Duodenal Homeobox-1; NRC; normal rat cultured cholangiocytes; BDL; bile duct ligation; cAMP; cyclic adenosine 3′,5′-monophosphate; FBS; fetal bovine serum; PKA; protein kinase A; PI3K; phosphatidyl-inositol-3-kinase; PCNA; proliferat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Fluorescent in situ hybridization reveals multiple expression domains for SpBrn1/2/4 and identifies a unique ectodermal cell type that co-expresses the ParaHox gene SpLox

Keywords: Pdx-1; Pou III; Ectodermal cell specification; Ancestral cell types; Molecular fingerprints; Triple in situ hybridization

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Effects of exposure of human islet beta-cells to normal and high glucose levels with or without gliclazide or glibenclamide

Keywords: Pancreatic islets; Gliclazide; Glibenclamide; PDX-1; Ki67Îlots pancréatiques humains; Gliclazide; Glibenclamide; PDX-1; Ki67

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Role of MafA in pancreatic β-cells

Keywords: Pancreatic β-cell; Insulin; MafA; PDX-1; NeuroD; Transcription factor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia

Keywords: Diabetes; Cellular therapy; Mesencymal stem cells; PDX-1; Regulatory T cells

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

The Expression Pattern of PDX-1, SHH, Patched and Gli-1 Is Associated with Pathological and Clinical Features in Human Pancreatic Cancer

Keywords: Pancreatic carcinoma; Embryonic markers; Pancreas duodenum homeobox 1; PDX-1; Sonic hedgehog; SHH; Survival;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase

Keywords: PDX-1; PI3K; Insulin; Pancreatic regeneration; Duct differentiation; β-Cell differentiation; Wortmannin; siRNA;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic β-cells

Keywords: ALK7; Smads; Insulin promoter; PDX-1; Pancreatic β-cell

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Transcriptional mechanism of suppression of insulin gene expression by AMP-activated protein kinase activator 5-amino-4-imidazolecarboxamide riboside (AICAR) in β-cells

Keywords: BETA2, β-cell E-box transcription factor; Pdx-1, pancreatic duodenal homeobox-1; AMPK, AMP-activated kinase; AICAR, 5-amino-4-imidazolecarboxamide ribosideATCAR; AMPK; BETA2; Insulin; Pdx-1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

An immunohistochemical study of the endocrine pancreas of the African ice rat, Otomys sloggetti robertsi

Keywords: Pancreas; Otomys; PDX-1; Insulin; Glucagon; Somatostatin; Transcription factors

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell

Keywords: Diabetes mellitus; Islets of Langerhans; PDX-1; Ngn3; Insulin gene

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

The morphology of islets of Langerhans is only mildly affected by the lack of Pdx-1 in the pancreas of adult Meriones jirds

Keywords: Pancreas; Meriones; Pdx-1; Insulin; Glucagon; Somatostatin; Transcription factors; Endocrine; Gerbillinae; Maf

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Development of β-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat

Keywords: pancreas transplantation; type 2 diabetes; SDT rats; native pancreas; PDX-1; development; β-cell

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

PDX-1 Expression Is Associated with Islet Proliferation In Vitro and In Vivo

Keywords: PDX-1; islet proliferation; β-cell differentiation; somatostatin receptors; SSTR1; SSTR2; SSTR5; p27; p38; Ex-4; GLP-1; pancreas growth

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage

Keywords: Glucose-dependent insulinotropic polypeptide; GIP; Insulin; Gene expression; GATA-4; PDX-1; ISL-1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

Keywords: Pancreas; Islet; Development; Multipotent progenitor cell; Insulin; Pdx-1; Ptf1a; Ngn3; MafA; Recombinase mediated cassette exchange;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه