کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2196066 1550890 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression, signaling and function of Egr transcription factors in pancreatic β-cells and insulin-responsive tissues
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Expression, signaling and function of Egr transcription factors in pancreatic β-cells and insulin-responsive tissues
چکیده انگلیسی


• Egr proteins are zinc finger transcription factors.
• The activity of Egr transcription factors is controlled via the biosynthesis.
• Glucose, neurosteroids, and GPCR ligands upregulate EGR-1 expression and activity.
• Egr proteins regulate insulin biosynthesis, glucose homeostasis, and islet size.
• Egr-1 is an integral part of insulin receptor signaling.

Egr-1 and the related zinc finger transcription factors Egr-2, Egr-3, and Egr-4 are stimulated by many extracellular signaling molecules and represent a convergence point for intracellular signaling cascades. Egr-1 expression is induced in insulinoma cells and pancreatic β-cells following stimulation with either glucose, or pregnenolone sulfate. Moreover, stimulation of Gαq and Gαs-coupled receptors enhances EGR-1 gene transcription. Functional studies revealed that Egr transcription factors control insulin biosynthesis via regulation of Pdx-1 expression. Glucose homeostasis and pancreatic islet size are regulated by Egr transcription factors, indicating that these proteins control central physiological parameters regulated by pancreatic β-cells. In addition, Egr-1 is an integral part of the insulin receptor signaling cascade in insulin-responsive tissues and influences insulin resistance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 388, Issues 1–2, 5 May 2014, Pages 10–19
نویسندگان
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