کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071602 1544604 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of MafA in pancreatic β-cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Role of MafA in pancreatic β-cells
چکیده انگلیسی

Pancreatic β-cell-specific insulin gene expression is regulated by a variety of pancreatic transcription factors and the conserved A3, C1 and E1 elements in the insulin gene enhancer region are very important for activation of insulin gene. Indeed, PDX-1 binding to the A3 element and NeuroD binding to the E1 element are crucial for insulin gene transcription. Recently, C1 element-binding transcription factor was identified as MafA, which is a basic-leucine zipper transcription factor and functions as a potent transactivator for the insulin gene. Under diabetic conditions, chronic hyperglycemia gradually deteriorates pancreatic β-cell function, which is accompanied by decreased expression and/or DNA binding activities of MafA and PDX-1. Furthermore, MafA overexpression, together with PDX-1 and NeuroD, markedly induces insulin biosynthesis in various non-β-cells and thereby is a useful tool to efficiently induce insulin-producing surrogate β-cells. These results suggest that MafA plays a crucial role in pancreatic β-cells and could be a novel therapeutic target for diabetes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 61, Issues 7–8, 2 July 2009, Pages 489–496
نویسندگان
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