کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837954 | 1612896 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link
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کلمات کلیدی
phosphoinositide-dependent protein kinase 1PS1GDSPP-1NFTsMMSEGPCRsIRS-1GSK-3βIGF-1FFAsAPPGCAPDX-1iNOSAβSPSJnkPDK1NODPI3KADAS-CogSTAT3CREBG protein-coupled receptors - G گیرنده های پروتئینی همراهpresenilin 1 - Presenilin 1β-Amyloid - β-آمیلوئیدAkt - آکتFree fatty acids - اسیدهای چرب آِزادinsulin-like growth factor-1 - انسولین مانند عامل رشد 1insulin receptor substrate-1 - انسولین گیرنده زیربخش 1Mini-Mental Status Examination - بررسی وضعیت مینی روانیAlzheimer’s disease - بیماری آلزایمرDiabetes mellitus - دیابت قندیNon-obese diabetic - دیابتی غیر چاقیinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییsenile plaques - صفحات سالخوردهphosphoinositide 3-kinase - فسفینوزیتید 3-کینازGeriatric Depression Scale - مقیاس افسردگی حاملگیneurofibrillary tangles - مگس های نوروفیبریلیالcAMP-response element binding protein - پروتئین اتصال دهنده عنصر cAMPprotein phosphatase 1 - پروتئین فسفاتاز 1amyloid precursor protein - پروتئین پیش ماده آمیلوئیprotein kinase B - پروتئین کیناز BGlycogen synthase kinase-3β - گلیکوزین سنتاز کیناز 3βglycogen synthase - گلیکوژن سنتاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link](/preview/png/8837954.png)
چکیده انگلیسی
It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM), and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and DM is still unclear. Recently, more and more evidence has shown that glycogen synthase kinase-3β (GSK-3β) may be the potential link between DM and AD. In DM, GSK-3β is the crucial enzyme of glycogen synthesis, which plays a key role in regulating blood glucose. More importantly, GSK-3β is one of the key factors leading to insulin deficiency and insulin resistance, and insulin resistance is an important hallmark of the occurrence and development of DM. In AD, GSK-3β plays an important role in hyperphosphorylation of microtubule-associated protein tau (tau), which is one of the pathological features in AD. GSK-3β is one of the important kinases of tau phosphorylation and is involved in the insulin/phosphoinositide 3-kinase/protein kinase B (insulin/PI3K/Akt) signaling pathway. Dysfunction of the insulin/PI3K/Akt signaling pathway, which regulates glucose metabolism in the brain, can lead to tau hyperphosphorylation in the brain of AD patents. Additionally, insulin resistance in DM may cause β-amyloid (Aβ) deposition, which will be cleared by tau, but excessive phosphorylation of tau will further aggravate the neurotoxicity; then damage the brain and affect the cognitive function. GSK-3β is considered as a common kinase in insulin signaling transduction and tau protein phosphorylation, so we have reasons to believe that GSK-3β is a potential link between DM and AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 339, 26 February 2018, Pages 57-65
Journal: Behavioural Brain Research - Volume 339, 26 February 2018, Pages 57-65
نویسندگان
Ying Zhang, Nan-qu Huang, Fei Yan, Hai Jin, Shao-yu Zhou, Jing-shan Shi, Feng Jin,