کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837954 | 1612896 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
phosphoinositide-dependent protein kinase 1PS1GDSPP-1NFTsMMSEGPCRsIRS-1GSK-3βIGF-1FFAsAPPGCAPDX-1iNOSAβSPSJnkPDK1NODPI3KADAS-CogSTAT3CREBG protein-coupled receptors - G گیرنده های پروتئینی همراهpresenilin 1 - Presenilin 1β-Amyloid - β-آمیلوئیدAkt - آکتFree fatty acids - اسیدهای چرب آِزادinsulin-like growth factor-1 - انسولین مانند عامل رشد 1insulin receptor substrate-1 - انسولین گیرنده زیربخش 1Mini-Mental Status Examination - بررسی وضعیت مینی روانیAlzheimer’s disease - بیماری آلزایمرDiabetes mellitus - دیابت قندیNon-obese diabetic - دیابتی غیر چاقیinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییsenile plaques - صفحات سالخوردهphosphoinositide 3-kinase - فسفینوزیتید 3-کینازGeriatric Depression Scale - مقیاس افسردگی حاملگیneurofibrillary tangles - مگس های نوروفیبریلیالcAMP-response element binding protein - پروتئین اتصال دهنده عنصر cAMPprotein phosphatase 1 - پروتئین فسفاتاز 1amyloid precursor protein - پروتئین پیش ماده آمیلوئیprotein kinase B - پروتئین کیناز BGlycogen synthase kinase-3β - گلیکوزین سنتاز کیناز 3βglycogen synthase - گلیکوژن سنتاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM), and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and DM is still unclear. Recently, more and more evidence has shown that glycogen synthase kinase-3β (GSK-3β) may be the potential link between DM and AD. In DM, GSK-3β is the crucial enzyme of glycogen synthesis, which plays a key role in regulating blood glucose. More importantly, GSK-3β is one of the key factors leading to insulin deficiency and insulin resistance, and insulin resistance is an important hallmark of the occurrence and development of DM. In AD, GSK-3β plays an important role in hyperphosphorylation of microtubule-associated protein tau (tau), which is one of the pathological features in AD. GSK-3β is one of the important kinases of tau phosphorylation and is involved in the insulin/phosphoinositide 3-kinase/protein kinase B (insulin/PI3K/Akt) signaling pathway. Dysfunction of the insulin/PI3K/Akt signaling pathway, which regulates glucose metabolism in the brain, can lead to tau hyperphosphorylation in the brain of AD patents. Additionally, insulin resistance in DM may cause β-amyloid (Aβ) deposition, which will be cleared by tau, but excessive phosphorylation of tau will further aggravate the neurotoxicity; then damage the brain and affect the cognitive function. GSK-3β is considered as a common kinase in insulin signaling transduction and tau protein phosphorylation, so we have reasons to believe that GSK-3β is a potential link between DM and AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 339, 26 February 2018, Pages 57-65
Journal: Behavioural Brain Research - Volume 339, 26 February 2018, Pages 57-65
نویسندگان
Ying Zhang, Nan-qu Huang, Fei Yan, Hai Jin, Shao-yu Zhou, Jing-shan Shi, Feng Jin,