Keywords: gck; glucokinase; pfkm; phosphofructokinase (muscle); pfkl; phosphofructokinase (liver); pkm; pyruvate kinase (muscle); pklr; pyruvate kinase (liver and red blood cell); pck; phosphoenol pyruvate carboxykinases (cytosolic pck1 and mitochondrial pck2); fbp
مقالات ISI (ترجمه نشده)
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Keywords: Runx2; Runt-related transcription factor-2; Osx; Oster; Alp; alkaline phosphatase; Col1a1; collagen type I alpha 1; Atf4; activating transcription factor 4; LDHA; lactate dehydrogenase A; PDK1; pyruvate dehydrogenase kinase 1; TCA; tricarboxylic acid; FND
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; AChEIs; acetylcholinesterase inhibitors; ASD; Autism Spectrum Disorder; BuChE; pseudocholinesterase; EDs; endocrine disruptors; PIP2; phosphatidylinositol (3,4)-bisphosphate; PIP3; phosphatidylinositol (3,4,
Keywords: AUC; area under the curve; ChIH; chronic intermittent hypoxia; CPAP; continuous positive airway pressure; FID; free induction decays; FIO2; fraction of inspired oxygen; FMO3; flavin-containing monooxygenase-3; GAMT; guanidinoacetate methyltransferase; GLU
Keywords: ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related; AMPK; AMP-activated protein kinase; AD; Alzheimer's disease; ARE; antioxidant response element; ATF6; activating transcription factor 6; BiP; binding immunoglobulin protein; BRAC1; Breast cancer 1
Keywords: ACSVL3; acyl-coA synthetase VL3; ALDH1; aldehyde dehydrogenase; ALDOA; aldolase A; ALDOC; aldolase C; AMPK; 5â² AMP-activated protein kinase; ASNS; asparagine synthetase; BTICs; brain tumor initiating cells; 3-BrOP; 3-bromo-2-oxopropionate-1-propyl ester
Keywords: 27-HC; 27-Hydroxycholesterol; 3PO; 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one; ABCG1; ATP-binding cassette subfamily G1; ACBA1; ATP-binding cassette subfamily A1; ACC1; Acetyl-Co-A carboxylase-1; AKAP4; A-kinase anchoring protein 4; ALDO; Aldolase; AM
Keywords: 56MESS; (1S2S-diaminocyclohexane)platinum(II)] dichloride; AIBN; 2,2â²-azobisisobutyronitrile; Apt; aptamer; AUC; area under curve; BBR3464; (trans,trans,trans)-bis-mu-(hexane-16-diamine)-mu-[diammineplatinum(II)]bis[diammine(chloro)platinum(II)] tetrani
Keywords: D2R; dopamine receptor; cAMP; cyclic adenosine monophosphate; PKA; protein kinase A; DARPP-32; dopamine and cAMP-regulated phosphoprotein; PP1; protein phosphatase 1; MEK; mitogen-activated protein kinase/ERK kinase; ERK; extracellular-signal regulated ki
Keywords: DCA; Dichloroacetate; ECAR; extra cellular acidification rate; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolycarbocyanine; MMP; ÎÏm, mitochondrial membrane potential; NAD+; Â nicotinamide adenine dinucleotide; NADH; reduced nicoti
Keywords: (I-R); ischemia-reperfusion injury; IPC; ischemia preconditioning; ROS; reactive oxygen species; RNS; reactive nitrogen species; (ONOOâ); peroxynitrite; PI3K; phosphatidylinositol 3-kinase; PIP3; phosphatidyl-inositol 3,4,5-triphosphate; PIP2; phosp
Keywords: ALP; alkaline phosphatase; AXL; Axl receptor tyrosine kinase; Col-I; collagen-I; CSC; cancer stem cell; CTL; cytotoxic T lymphocyte; ECM; extracellular matrix; EPC; endothelial precursor cell; EV; extracellular vesicles; FN; Fibronectin; GAS6; growth arre
Keywords: 4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; aCDase; acid ceramidase; Akt; Akt/protein kinase B; aSMase; acid sphingomyelinase; CalA; calyculin A; CAPP; ceramide activated protein phosphatase; CDase; ceramidase; Cer; ceramide; Des
Keywords: AbA; Aureobasidin A; ABC; ATP-binding cassette; AMPK; AMP-activated protein kinase; ATG; Autophagy-related; ATP; Adenosine triphosphate; C1P; Ceramide-1-phosphate; CERS; Ceramide synthase; CK2; Casein kinase II; CLS; Chronological lifespan; CMA; Chaperone
Keywords: CAF; carcinoma associated fibroblasts; CAM; chick chorioallantoic membrane; DPI; diphenylene; EC; endothelial cell; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; HIF; hypoxia inducible factor; HMVEC; human microvascular endothelial
Keywords: ACLY; ATP citrate lyase; AKT; protein kinase B; ATP; adenosine triphosphate; ANT; adenine nucleotide translocator; AMPK; AMP-activated protein kinase; COX; cytochrome c oxidase; EGFR; epidermal growth factor receptor; ERRα; estrogen-related receptor alph
Keywords: Lipid rafts; Signal transduction; IGF-I/PI3K/Akt signaling; Fas/CD95; CASMER; Cancer; APL; alkylphospholipid analogue; CASMER; cluster of apoptotic signaling molecule-enriched rafts; DED; death effector domain; DD; death domain; DISC; death-inducing signa
Keywords: AC; adenylyl cyclase; AKT; protein kinase B; AMPK; AMP-activated protein kinase; AnR; androgen receptor; ARF6; ADP ribosylation factor 6; CaMK; Ca2+-calmodulin dependent kinase; CaMKK; CaMK kinase; cAMP; cyclic adenosine 3â²,5â²-monophosphate; CDK5; cyc
Keywords: 2DG; 2-deoxy-glucose; 6-AN; aminocicotinamide; ABC; ATP-binding cassette transporter; CSCs; cancer stem cells; DCA; dichloroacetate; G6PD; glucose-6-phosphate dehydrogenase; GLUT; glucose transporter; HIF; hypoxia-inducible factors; HK2; hexokinase 2; Kra
Keywords: Orexin; Hypocretin; Phospholipase; Endocannabinoid; Ion fluxes; 2-AG; 2-arachidonoylglycerol; AA; arachidonic acid; anandamide; N-arachidonoylethanolamine; CNS; central nervous system; cPLA2 and iPLA2; cytosolic (Ca2+-dependent) and intracellular (Ca2+-in
Keywords: 4E-BP; 4E binding protein; AP-1; activator protein-1; Ad-AH; EBV-negative adenocarcinoma cell line; Akt; serine/threonine kinase; ARNT; aryl hydrocarbon receptor nuclear translocator; ATP/ADP; adenosine tri- or diphosphate; CAIX and CAXII; carbonic anhydr
Keywords: Akt; protein kinase B; DHA; docosahexaenoic acid; ERK; extracellular signal-regulated protein kinase; NAPE; N-acylphosphatidylethanolamine; PC; phosphatidylcholine; PDK1; phosphoinositide-dependent kinase-1; PE; phosphatidylethanolamine; PEMT; phosphatidy
Keywords: APM; antigen processing machinery; BMI; body mass index; CTLs; cytotoxic T-cells; DC; dendritic cells; DCA; dichloroacetate; ERK; extracellular signal-regulated kinases; GTN; glyceryl trinitrate; HAT; histone acetyltransferases; HLA; human leukocyte antig
Keywords: 4E-BP1; eIF4E binding protein 1; 5â²-UTR; 5â²-untranslated region; AMPK; AMP-activated protein kinase; eIF; eukaryotic initiation factor; GCN2; general-control nonderepressible; GEF; guanine nucleotide exchange factor; GSK-3; glycogen synthase kinase-3;
Keywords: AP-1; adaptor protein 1; ASL; airway surface liquid; CCO; cytochrome c oxidase; CF; cystic fibrosis; COX-2; cyclooxygenase 2; Csk; c-src kinase; DMEM; Dulbeccos' minimal essential medium; DMT1; divalent metal ion transporter 1; DUOX; dual oxidase; EGFR;
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
Keywords: ER; estrogen receptor; mTORC2; mammalian target of rapamycin complex 2; PDK1; phosphoinositide-dependent kinase-1; PH; pleckstrin homology; PI3K; phosphatidylinositol 3-kinase; PX; Phox; SGK; serum and glucocorticoid inducible protein kinase; SGK; AKT; PI
MiR-183 promotes preadipocyte differentiation by suppressing Smad4 in goats
Keywords: PPARγ; peroxisome proliferator-activated receptor γ; C/EBPα; CCAAT/enhancer binding protein α; FAS; fatty acid synthase; TGFβ; transforming growth factor β; LRP6; low density lipoprotein receptor related protein 6; SREBP-1c; sterol regulatory elemen
Emerging microRNAs in cancer diagnosis, progression, and immune surveillance
Keywords: Cancer immunity; miR-21; miR-375; oncomiR; Prognostic biomarker; RAS pathway; AKT; serine/threonine-protein kinase; CIP2A; cancerous inhibitor of PP2A; ERK; extracellular-signal-regulated kinase; FFPE; formalin-fixed, paraffin-embedded; HNC; head and neck
MicroRNA-375 inhibits the proliferation, migration and invasion of kidney cancer cells by triggering apoptosis and modulation of PDK1 expression
Keywords: Kidney cancer; PDK1; miR-375; Proliferation; Cell migration;
Design, synthesis, crystal structures and anticancer activity of 4-substituted quinolines to target PDK1
Keywords: PDK1; Quinoline; Induced fit docking, A549 inhibitor;
Expression patterns of claudin-5 and its related signals during luteal regression in pseudopregnant rats: The enhanced effect of additional PGF treatment
Keywords: CL; corpus luteum; ECL; enhanced chemoluminescence; mTORC2; mammalian target of rapamycin complex 2; MAPK; mitogen-activated proteinkinases; PGF; prostaglandinF2α analogue; PGF2α; prostaglandinF2α; P4; progesterone; p-ERK; phosphorylated ERK1/2; p-p38;
X-inactive-specific transcript: A long noncoding RNA with complex roles in human cancers
Keywords: AR; androgen receptor; ATG7; autophagy related 7; Bcl2; B-cell lymphoma-2; BRCA1; breast cancer-associated protein 1; CCND1; cyclin D1; CDK4/6; cyclin dependent kinase 4/6; CDX1; caudal type homeobox 1; CRC; colorectal cancer; EMT; epithelial mesenchymal
PDK1 regulates definitive HSCs via the FOXO pathway during murine fetal liver hematopoiesis
Keywords: FL; fetal liver; YS; yolk sac; HSCs; hematopoietic stem cells; PDK1; phosphoinositide dependent kinase-1; BFU-E; erythroid burst-forming units; GEMM; granulocyte, erythrocyte, monocyte, megakaryocyte- forming unit; CFU-GM; granulocyte-macrophage colony-fo
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1α-mediated apoptosis
Keywords: HIF-1α; hypoxia-inducible factor alpha 1; DMAP; 4 dimethyamino- pyridine; DCC; N, N' dicyclohexylcarbodiimide; DMEM; Dulbecco's modified Eagle's medium; MTT; 3-(4 5-dimethyl-2-thiazolyl)-2 5-diphenyl-2-H-tetrazolium bromide; IC50; Half of maximal i
KRAS-Mutant non-small cell lung cancer: From biology to therapy
Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete
The spatial molecular pattern of integrin recognition sites and their immobilization to colloidal nanobeads determine α2β1 integrin-dependent platelet activation
Keywords: Platelet signaling; Platelet activation; Integrin α2β1 cluster; Nanopatterning; Biofunctionalized nanobeads and nano-sized membrane protein clusters; BCECF-AM; 2â²,7â²-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein-acetoxymethyl ester; BSA; bovine
Influence of silibinin and β-β-dimethylacrylshikonin on chordoma cells
Keywords: Chordoma; β-β-dimethylacrylshikonin; Silibinin; Apoptosis; ACTB; actin beta; AKT; AKT serine/threonine kinase; BAD; BCL2 associated agonist of cell death; BAK; BCL2 antagonist/killer; BAX; BCL2 associated X protein; BCL-2; B cell leukemia/lymphoma 2; BH
Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link
Keywords: 3xTg; triple-transgenic; Aβ; β-amyloid; AD; Alzheimer's disease; ADAS-cog; Alzheimer's Disease Assessment Scale-cognitive subscale; Akt; protein kinase B; APP; amyloid precursor protein; CREB; cAMP-response element binding protein; DM; diabetes mell
Therapeutic applications of zebrafish (Danio rerio) miRNAs linked with human diseases: A prospective review
Keywords: miRNA; Micro RNA; RNA; Ribonucleic acid; RNase III; Ribonuclease III; mRNA; Messenger RNA; RISC; RNA-induced silencing complex; UTR; Untranslated region; Pre-miRNA; Precursor micro RNA; DGCR8; Digeorge syndrome chromosomal [or critical] region 8; TRBP; Tr
The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling
Keywords: Cardenolide; Coronavirus; Na+/K+-ATPase; Ouabain; PI3K; PDK1;
F2-isoprostanes affect macrophage migration and CSF-1 signalling
Keywords: Akt; Protein Kinase B; BMM; Bone Marrow derived Macrophages; BSA; Bovine Serum Albumin; Chol-IsoP; Cholesterol-Isoprostane; CSF-1; Colony Stimulating Factor-1; CSF-1R; Colony Stimulating Factor-1 Receptor; DAPI 4â²; 6-Diamidino-2-phenylindole; DMSO; Dime
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
Differentially DNA methylation changes induced in vitro by traffic-derived nanoparticulate matter
Keywords: nPM; nanoparticulate matter; PM; particulate matter; ROS; reactive oxygen species; HUVECs; human umbilical vein endothelial cells; DMP; differential methylated probes; GO; gene ontology; DMGs; differential methylated genes; KEGG; Kyoto encyclopedia of gen
AGC kinases, mechanisms of regulation âand innovative drug development
Keywords: AGC kinase; group of kinases related to PKA PKG and PKC; PKA; protein kinase A; PKC; protein kinase C; PKG; protein kinase G; PRK; protein kinase C related kinase (also termed PKN protein kinase N); PDK1; 3-phosphoinositide-dependent protein kinase 1; PKB
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Keywords: Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto
Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes
Keywords: Cytomegalovirus; Monocytes; Small-molecule inhibitor; HCMV; human cytomegalovirus; h; hour; EGF; epidermal growth factor; EGFR; EGF receptor; αvβ3; alpha v beta 3 integrin; gB; glycoprotein B; gH; glycoprotein H; PI3K; phosphoinositide 3-kinase; PTEN; p
Paving the Rho in cancer metastasis: Rho GTPases and beyond
Keywords: ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMT; amoeboid-mesenchymal transition; APC; adenomatosis polyposis coli; Arp2/3; actin related protein 2/3; Cdc42; cell division control protein 42 homolog; CK1; casein kinase 1; COX-2; cyclooxygena
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Keywords: AGEs; advanced glycation end products; AP-1; activating protein -1; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; BMI; body mass index; CAF; cafeteria diet; CAT; Catalase; CBMN-Cyt; cytokinesis block micronucleus cytome assay; CEL
Novel function of Porphyromonas gingivalis gingipains in the PI3K/Akt signaling pathway
Keywords: PI3K; phosphatidylinositol-3 kinase; GSK3; glycogen synthase kinase 3; mTOR; mammalian target of rapamycin; PDK1; 3-phosphoinositide-dependent protein kinase 1; LPS; lipopolysaccharide; Porphyromonas gingivalis; Virulence factors; Gingipains; PI3K/Akt sig