دانلود مقالات ISI درباره Pdk1 + ترجمه فارسی

Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway

Keywords: HLJDD; Huang-Lian-Jie-Du-Decotion; MCAO; middle cerebral artery occlusion; TTC; 2,3,5-triphenyltetrazolium chloride; HE; hematoxylin-eosin; NO; nitric oxide; MDA; malondialdehyde; GSH; glutathione; GSSG; glutathione disulfide; T-SOD; total superoxide di

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Astrocytic phosphorylation of PDK1 on Tyr9 following an excitotoxic lesion in the mouse hippocampus

Keywords: PDK1; Epilepsy; Neurodegerative disease; Astrocyte; Phosphorylation; Cell signaling

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases

Keywords: AGC kinase; PIF-pocket; Allosterism; PDK1; PRK; atypical PKC

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2013 سفارش ترجمه

β-Arrestin signal complex plays a critical role in adipose differentiation

Keywords: GHSR1a; growth hormone secretagogue receptor type 1a; PPARγ; peroxisome proliferator-activated receptor; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT/enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; PI3K; phosphatidy

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2013 سفارش ترجمه

Dendritic spine plasticity as an underlying mechanism of neuropathic pain: Commentary on Tan et al.

Keywords: AMPA; 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid; aPKC; atypical protein kinase C; BDNF; brain derived neurotrophic factor; CCI; chronic constriction injury; DHPG; dihydroxyphenyglycine; FMRP; fragile X mental retardation protein; IL-6; inte

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues

Keywords: TPCK; N-alpha-tosyl-l-phenylalanyl chloromethyl ketone; PDK1; 3-phosphoinositide dependent protein kinase-1; AGC; related to protein kinase A, protein kinase G and protein kinase C; RSK; ribosomal S6 kinase; S6K; S6 kinase; PKA; protein kinase A; ERK; ext

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2α system

Keywords: GAAC; general amino acid control; HM; hydrophobic motif; PIF; PDK1-interacting fragment; Yeast; Gcn2; PDK1; Pkh1-3; PKA; Sch9; PKB;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation

Keywords: Hsp90; heat shock protein 90; HCV; hepatitis C virus; RdRp; RNA-dependent RNA polymerase; 17-DMAG; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; PDK1; phosphoinositide-dependent kinase-1; PRK2; protein kinase C-related kinase 2; Hsp90 inhibitor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Increase in phosphorylation of PDK1 and cell survival after acute spinal cord injury

Keywords: PDK1; 3-Phosphoinositidedependent protein kinase-1; PKB; protein kinase B; PIP3; phosphoinositol 3,4,5-triphosphate; CNS; Central nervous system; SCI; Spinal cord injury; SDS; Sodium dodecyl sulfate; PAGE; Polyacrylamide gel electrophoresis; BSA; Bovine s

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

c-Jun N-terminal kinase controls a negative loop in the regulation of glial fibrillary acidic protein expression by retinoic acid

Keywords: GFAP; c-Jun N-terminal kinase; retinoic acid; neural precursor cells; BMP-2; bone morphogenetic protein-2; DNA-PKcs; DNA-protein kinase catalytic subunit; ERK; extracelular-regulated kinase; GFAP; glial fibrillary acidic protein; GSK-β; glycogen synthase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1

Keywords: Os-ME; methanol extract of Osbeckia stellata; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-alpha; ERK; extracellular signal-related kinase; TLR; toll-like receptor; MAPK; mitogen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes

Keywords: BCA; bicinchoninic acid protein; ECL; enhanced chemiluminescence; IR; insulin receptor; mTOR; mammalian target of rapamycin; mTORC1; mammalian target of rapamycin complex 1; mTORC2; mammalian target of rapamycin complex 2; NODAT; new onset diabetes after

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice

Keywords: AMPK; AMP-dependent kinase; FAS; fatty acid synthases; GSK-3β; glycogen synthase kinase-3β; IGF-1; insulin-like growth factor-1; PDK1; phosphoinositide-dependent protein kinase 1; PDGF; platelet-derived growth factor; PI3K; phosphatidylinositol 3 kinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Redox-regulating role of insulin: The essence of insulin effect

Keywords: 4-HNE; 4-hydroxynonenal; 8-OHdG; 8-hydroxydeoxyguanosine; 8-OHG; 8-hydroxyguanine; 8-iso-PGF2α; 8-iso-prostaglandin F2α; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Akt; protein kinase B; AMI; acute myocardial infarction; APS; a

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

Keywords: Liver Cancer; mRNA Processing; Gene Expression; Cell Death; GFP; green fluorescent protein; HCC; hepatocellular carcinoma; mRNA; messenger RNA; miRNA; microRNA; mTOR; mammalian target of rapamycin; PCR; polymerase chain reaction; PDK1; 3′-phosphoinositi

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner

Keywords: PDK1; 3-phosphoinositide-dependent protein kinase 1; PI3K; phosphatidylinositol 3 kinase; PIP3; phosphatidylinositol 3,4,5 triphosphate; PH; pleckstrin homology; shRNA; short hairpin RNA;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

Keywords: EGCG; (−)-epigallocatechin-3-gallate; PI3K; phosphoinositide-3-kinase; mTOR; mammalian target of rapamycin; PI(3,4,5)P3; phosphatidylinositol-3,4,5-triphosphate; ATP; adenosine 5′-triphosphate; mTORC2; mammalian target of rapamycin complex 2; FRAP1; F

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Keywords: PDK1; Selective; Tethering; Pyridinone; DFG-out; Fragment-based drug discovery

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer

Keywords: Colon cancer; Rectal cancer; S6K; RSK; PDK1; Akt; CIMP+; KRAS2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays

Keywords: PDK1; AKT; Kinase inhibitor; Signal transduction; Template-directed assembly (TDA)

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Structure-based optimization of potent PDK1 inhibitors

Keywords: Kinase; Structure-based drug design; PDK1; CDK2; Scaffold;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1

Keywords: 3-Phosphoinositide-dependent kinase-1; PDK1; Allosteric activators; AGC protein kinases; PIF pocket

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Addiction to protein kinase CK2: A common denominator of diverse cancer cells?

Keywords: ALCL; anaplastic large cell lymphoma; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CML; chronic myeloid leukemia; MDR; multi-drug resistance; MM; multiple myeloma; NF-kB; nuclear factor-kB; PDK1; 3′-phosphoinositide-dependent kinase-1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

Keywords: AMPK; AMP-activated protein kinase; CHAPS; 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonic acid; 2,7-DCFH-DA; 2,7 Dichlorodihydrofluorescein diacetate; DTT; dithiothreito; EGFR; epidermal growth factor receptor; MDA; malondialdehyde; mSin1; mamm

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Research ArticleSynergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation

Keywords: HCC; Sorafenib; Proteasome inhibitor; Akt; Apoptosis; PP2A; Molecular targeted therapy; HCC; hepatocellular carcinoma; HBV; hepatitis B virus; HCV; hepatitis C virus; PP2A; protein phosphatase 2A; PI3K; phosphatidylinositol-3-kinase; PDK1; phosphatidylino

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Modulation in Activation and Expression of Phosphatase and Tensin Homolog on Chromosome Ten, Akt1, and 3-Phosphoinositide-Dependent Kinase 1: Further Evidence Demonstrating Altered Phosphoinositide 3-Kinase Signaling in Postmortem Brain of Suicide Subject

Keywords: Akt; depression; hippocampus; PDK1; prefrontal cortex; PTEN; suicide

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Malt1 and cIAP2-Malt1 as effectors of NF-κB activation: Kissing cousins or distant relatives?

Keywords: MALT; mucosa associated lymphoid tissue; cIAP2; cellular inhibitor of apoptosis 2; IKK complex; inhibitor of κB kinase; TCR; T cell receptor; BCR; B cell receptor; Bcl10; B cell lymphoma 10; CARD; caspase associated recruitment domain; BIR; baculovirus I

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

Keywords: BNIP3; Glucose transporter; Glycolysis; HIF-1; Lactate dehydrogenase; MCT4; Mitochondrial autophagy; NHE1; Oxygen; PDK1; Warburg effect

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Considering the role of pyruvate in tumor cells during hypoxia

Keywords: ATP; adenosine(5′)triphosphate; acetyl-CoA; acetyl-coenzyme A; CAM; chorioallantoic membrane; NAD; nicotinamide adenine dinucleotide; NADH; dihydronicotinamide adenine dinucleotide; FGFR-2; fibroblast growth factor receptor 2; GSH; glutathione; HIF; hyp

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes

Keywords: Nucleus; PI3K; PDK1; Cardiomyocyte; Akt; Phosphoinositide;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1

Keywords: Phospholipid; PDK1; Akt; Src kinase; Nuclear localization; SHP-1/PTP1C;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells

Keywords: Cell size; Exocrine; β cell; Pancreas; Pdk1; Progenitors;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway

Keywords: PDK1; PI3K; Oncology; PI3K/PKB-pathway

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1)

Keywords: Custom gene synthesis; Intrinsic disorder; Disordered proteins; Autoinhibition; Phosphoinositide-dependent protein kinase-1; PDK1; Proteolysis inhibition; Minimal media;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Baculovirus-mediated expression, purification, and characterization of a fully activated catalytic kinase domain construct of the 70 kDa 40S ribosomal protein S6 kinase-1 αII isoform (S6K1αII)

Keywords: S6K1-T389E; Phosphoinositide-dependent protein kinase-1; PDK1; Sf9 insect cells; Baculoviral coinfection; ESI-TOF; MonoQ anion exchange; Protein phosphorylation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C

Keywords: AMPK; adenosine monophosphate-activated protein kinase; CHC; chronic hepatitis C; GSK-3β; glycogen synthase kinase-3 beta; IRS-1; insulin-receptor substrate 1; mTOR; mammalian target of rapamycin; PDK1; phosphoinositide-dependent kinase 1; PP2A; protein

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Serine 396 of PDK1 is required for maximal PKB activation

Keywords: PDK1; PKB; Akt; Protein phosphorylation; Signal transduction

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells

Keywords: PDK1; PKB/Akt; PI3K; Chemical genetics; AGC kinases; Apoptosis; Teratoma; Phosphorylation; BX-795; 1-NM-PP1

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

The nerve growth factor and its receptors in airway inflammatory diseases

Keywords: ADAM; a disintegrin and metalloprotease domain; AP-1; activating protein 1; AP-2; clathrin adaptative protein-2; APPL; amyloid precursor protein-like; ARMS; ankyrin repeat-rich membrane spanning; BDNF; brain-derived neurotrophic factor; bFGF; basic fibrob

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2008 سفارش ترجمه

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D

Keywords: ES cell; embryonic stem cell; p90RSK; p90 ribosomal S6 kinase; PDK1; 3′-phosphoinositide-dependent protein kinase-1; PKC; protein kinase C; PKD; protein kinase D; S6K1; 70-kilodalton ribosomal S6 kinase 1; PDK1; PKD; PKC;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Keywords: Ser/Thr kinases; PDK1; Akt; PI3-kinase; Cancer

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers

Keywords: Tetrocarcin A; PTEN; PI3-kinase; PDK1; Akt; Breast cancer; Apoptosis; Phosphorylation; Dephosphorylation; Survival factor; Bcl-2; Bcl-XL; Caspase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

The role of mitochondria in protection of the heart by preconditioning

Keywords: 5HD; 5-hydroxydecanoate; AMPK; AMP activated protein kinase; ANT; Adenine nucleotide translocase; APD; Action potential duration; BCDH; branched chain 2-oxoacid dehydrogenase; CrK; creatine kinase; CsA; cyclosporin A; CyP; cyclophilin; Cx43; connexin43; G

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2007 سفارش ترجمه

Antigen receptor regulation of phosphoinositide-dependent kinase 1 pathways during thymocyte development

Keywords: Thymocyte; Kinase; Signal transduction; T cell receptor; Pre T cell receptor; PDK1; S6K1; Thymus; TCR signaling

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults

Keywords: Learning; Music; BDNF; TrkB; MAPK; PDK1; Mice

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Protein kinase Cδ participates in insulin-induced activation of PKB via PDK1

Keywords: Protein kinase Cδ; Protein kinase B; PDK1; Insulin; Insulin signaling; Skeletal muscle; Glycogenesis; Glucose uptake

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Activation of a GST-tagged AKT2/PKBβ

Keywords: AKT; PKB; PDK1; Autophosphorylation; Baculovirus; Protein purification;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

The link between PKCα regulation and cellular transformation

Keywords: ASO; Antisense oligonucleotides; B-CLL; B lymphocyte-chronic lymphocytic leukaemia; DAG; diacylglycerol; IP3; inositol-1,4,5-triphosphate; ERK-MAPK; extracellular-signal regulated kinase-mitogen activated protein kinase; PIP2; phosphatidylinositol-4,5-bis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Targeting protein kinase C and “non-kinase” phorbol ester receptors: Emerging concepts and therapeutic implications

Keywords: DAG; diaclyclycerol; DGK; diacylglycerol kinase; ILV; indolactam V; FRET; Florescence Resonance Energy Transfer; PAH; polycyclic aromatic hydrocarbon; PDBu; phorbol 12, 13-dibutyrate; PDK1; phosphatidylinositide-dependent kinase 1; PKC; protein kinase C;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Dynamics of signaling by PKA

Keywords: cAMP; cyclic-3′, 5′-adenosine monophosphate; PKA; cAMP-dependent protein kinase; PKI; heat stable protein kinase A inhibitor; PDK1; phosphoinositide-dependent kinase-1; ATP; adenosine triphosphate; ADP; adenosine diphosphate; D/D domain; dimerization/

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه