Role for loss of nuclear PTEN in a harbinger of brain metastases
Keywords: Brain metastasis; PTEN; Subcellular localization; PDK1;
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PDK1 promotes apoptosis of chondrocytes via modulating MAPK pathway in osteoarthritis
Keywords: PDK1; Osteoarthritis apoptosis; Mapk; Interleukin-1&β;
A high-throughput microtiter plate assay for the discovery of active and enantioselective amino alcohol-specific transaminases
Keywords: Chiral vicinal amino alcohol; Transaminase; High-throughput screening; Microtiter plate assay; Enantioselective; TAm; transaminase; PDK1; 3-phosphoinositide-dependent protein kinase-1; EMB; ethambutol; HIV; human immunodeficiency virus; THF; tetrahydrofur
Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain
Keywords: PtdIns(3,4,5)P3; Pleckstrin homology (PH) domain; PDK1; Flavonoid; QSAR;
PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2
Keywords: Rheumatoid arthritis; Fibroblast-like synoviocytes; PDK1; RSK2;
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease
Keywords: AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc
Food consumption and activity levels increase in rats following intranasal Hypocretin-1
Keywords: Hypocretin-1; Orexin-A; Intranasal; Appetite; MAPK; PDK1;
Discovery of novel 7-azaindoles as PDK1 inhibitors
Keywords: PDK1; Kinase inhibitor; Structure-based design; Fragment-screening; Protein crystallography; Virtual screening
N â 3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells
Keywords: 2-NBDG; fluorescent glucose analog; ALA; alpha-linolenic acid; AMPK; AMP-activated protein kinase; AS160; AKT substrate of 160Â kDa; cpt1; carnitine palmitoyltransferase 1; DMEM; Dulbecco's modified eagle medium; DHA; docosahexaenoic acid; DPH; diphenyl-h
The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators
Keywords: PKC; protein kinase C; IPC; ischemic pre conditioning; RACK; receptor for activated C-kinase; DAG; diacylglycerol; beta COP; coatomer subunit beta; CHOK1; chinese hamster ovary K1; CVD; cardiovascular disease; mKATP; ATP-sensitive mitochondrial potassium
Increased expression of platelet-derived growth factor associated protein-1 is associated with PDGF-B mediated glioma progression
Keywords: GBM; glioblastoma multiforme; PDGF; platelet-derived growth factor; PDAP-1; platelet-derived growth factor associated protein-1; PDK1; 3-phosphoinositide-dependent protein kinase 1; WHO; world Health Organization; TCGA; the cancer genome atlas; PI; propid
ADAMs family and relatives in cardiovascular physiology and pathology
Keywords: ADAM; A disintegrin and metalloproteinase; ADAM-TS; ADAM with thrombospondin domains; APP; amyloid precursor protein; APPsα; α-secretase-released N-terminal APP domain; C-domain; cysteine-rich domain; COMP; cartilage oligomeric matrix protein; DCM; dila
New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations
Keywords: ATP; adenosine triphosphate; BRAF; serine/threonine-protein kinase B-Raf; cAMP; cyclic adenosine monophosphate; CDK4; cyclin-dependent kinases 4; CREB; cAMP response element binding protein; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxi
Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation
Keywords: mTOR; mammalian target of rapamycin; UVB; ultraviolet-B; NMSC; non-melanoma skin cancer; mTORC1; mTOR complex 1; mTOC2; mTOR complex 2; AKT/PKB; protein kinase B; SCC; squamous cell carcinoma; ERK; extracellular-signal-regulated kinases; MEK; mitogen-acti
Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP
Keywords: Nrf2; Keap1; GSK-3; PKB/Akt; PI3K; PTEN; β-TrCP; ARE; antioxidant response element; tBHQ; tert-butyl hydroquinone; bZIP; basic-region leucine zipper; CDDO-Im; 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; CNC; cap'n'collar; Cul1; cullin-1; Cu
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2Â + signaling
Keywords: a.a.; amino acid; ATP; adenosine triphosphate; BH domain; Bcl-2-homology domain; BI-1; Bax inhibitor-1; BIRD-2; Bcl-2/IP3R disruptor-2; BRCA1; breast and ovarian cancer susceptibility gene 1; [Ca2Â +]cyt; cytosolic Ca2Â + concentration; CLL; chronic lymph
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α
Keywords: Akt; protein kinase B; AMPK; AMP-activated protein kinase; AVOs; acidic vesicular organelles; BNIP3; BCL2/adenovirus E1B 19Â kDa interacting protein 3; BNIP3L; BCL2/adenovirus E1B 19Â kDa interacting protein 3-like; CCND1; cyclin D1; CFSE; 5-(6)-carboxyfl
MiR-454 inhibited cell proliferation of human glioblastoma cells by suppressing PDK1 expression
Keywords: MiR-454; Glioblastoma; PDK1; Cell proliferation; Cell cycle
Threonine 34 phosphorylation by phosphoinositide-dependent protein kinase 1 facilitates dissociation of Akt from the plasma membrane
Keywords: Akt; protein kinase B; IGF; insulin-like growth factor; KD; kinase domain; MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MS; mass spectrometry; PDK; phosphoinositide-dependent protein kinase; PH; pleckstrin homology; PIK3; phospha
Phosphoinositide-dependent kinase 1 regulates leukemia stem cell maintenance in MLL-AF9-induced murine acute myeloid leukemia
Keywords: PDK1; Akt; MLL-AF9; AML; LSCs; Apoptosis
Therapy with radio-attenuated vaccine in experimental murine visceral leishmaniasis showed enhanced T cell and inducible nitric oxide synthase levels, suppressed tumor growth factor-beta production with higher expression of some signaling molecules
Keywords: Radio-attenuated Leishmania parasites; PDK1; PI3K; p38MAPK
PDK1 is a potential therapeutic target against angiosarcoma cells
Keywords: PDK1; Cyclin D; AKT-independent
p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy
Keywords: FAK; PDK1; Akt; p70S6K; S6; Autophagosomes;
Yeast-based methods to assess PTEN phosphoinositide phosphatase activity in vivo
Keywords: CWI; cell wall integrity; Gal; galactose; MAPK; mitogen-activated protein kinase; mTOR; mammalian target of rapamycin; PDK1; phosphoinositide-dependent kinase; PH; pleckstrin homology; PI3K; phosphoinositide 3-kinase; PtdIns(4,5)P2; phosphatidylinositol (
Hypoxia-induced IL-32β increases glycolysis in breast cancer cells
Keywords: ECAR; extracellular acidification rate; HIF-1; hypoxia inducible factor-1; IL-32; interleukin-32; LDH-A; lactate dehydrogenase A; OCR; oxygen consumption rate; OXPHOS; oxidative phosphorylation; PDK1; pyruvate dehydrogenase kinase; PFKFB4; fructose-2,6-bi
α-SMA-Cre-mediated excision of PDK1 reveals an essential role of PDK1 in regulating morphology of cardiomyocyte and tumor progression in tissue microenvironment
Keywords: PDK1; Knock-out mice; Heart failure; Tumor; MicroenvironmentPDK1; Souris knock-out; Dilatation cardiaque; Tumeur; Microenvironnement
Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus
Keywords: α-MSH; α-melanocyte-stimulating hormone; AC; adenylate cyclase; BDNF; brain-derived neurotrophic factor; CREB; cAMP responsive element binding protein; DAPI; 4â²,6-diamido-2-phenylindole dihydrochloride; ERK; extracellular signal-regulated kinase; GFAP
PI3K/Akt signaling in osteosarcoma
Keywords: OS; osteosarcoma; PI3K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog; mTOR; mammalian target of rapamycin; RTKs; receptor tyrosine kinases; PDGFR; platelet-derived growth factor receptor; IGF1R; insulin-like growth factor 1 receptor
ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells
Keywords: Akt/PKB; protein kinase B; CaM kinase-II; calcium/calmodulin-dependent protein kinase II; EGF; epidermal growth factor; ERK/Erk; extracellular-signal-regulated kinase activity/protein; GEF; guanine nucleotide-exchange factor; Itsn1; intersectin-1; MAPK/Ma
Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: Role of mTORC2/SGK1 pathway
Keywords: AFC; alveolar fluid clearance; AGC; protein kinase A, protein kinase G and protein kinase C; AKT; protein kinase B; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; AT II; type II alveolar epithelial cell; ENaC; epithelial sodium channel
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme
Keywords: PDK1 inhibitors; Kinase inhibitors; Oxindole derivatives; Glioblastoma; GBM stem cells; Multi-target therapy; PI3K; phosphatidylinositol-3-kinase; PDK1; phosphoinositide-dependent kinase-1; GSK3; Glycogen synthase kinase 3; CHK1; Checkpoint kinase-1; Akt;
MYC and metabolism on the path to cancer
Keywords: 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip
The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity
Keywords: PH; pleckstrin homology; PI3K; phosphatidylinositide 3-kinase; PIP3; phosphatidylinositol 3,4,5-trisphosphate; mTORC2; mammalian target of rapamycin complex 2; PDK1; phosphoinositide-dependent kinase 1; FasL; Fas ligand; GFP; green fluorescent protein; KO
Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components
Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4
GABARBP down-regulates HIF-1α expression through the VEGFR-2 and PI3K/mTOR/4E-BP1 pathways
Keywords: GABARBP; human γ-aminobutyrate type A (GABAA) receptor-binding protein; VEGF; vascular endothelial growth factor; HIF-1α; hypoxia-inducible factor-1α; PDK1; phosphoinositide-dependent protein kinase-1; mTOR; mammalian target of rapamycin; TSC-2; tubero
The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: Possible role of metalloproteinases
Keywords: PDK1, phosphoinositide-dependent protein kinase 1; PTEN, phosphatase and tensin homologUCN-01; PDK1; Protein kinase; Protein kinase inhibitor; Protein fragmentationUCN-01, (7-hydroxystaurosporine (3R*,8S*, 9R*, 10R*,12R*)-2,3,9,10,11,12-hexahydro-3-hydrox
Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor
Keywords: AcP; acid phosphatase; AI; androgen-independent; AS; androgen-sensitive; cPAcP; cellular prostatic acid phosphatase; CR PCa; castration-resistant prostate cancer; DSP; dual specificity phosphatase; EGFR; epidermal growth factor receptor; HER-2/ErbB-2/neu;
Insight into the structural mechanism for PKBα allosteric inhibition by molecular dynamics simulations and free energy calculations
Keywords: PKB/Akt; protein kinase B; MD; molecular dynamics; PI3K; phosphatidylinostiol-3-kinase; PDK1; 3â²-phosphoinositide-dependent kinase-1; PTEN; phosphatase and tensin homolog; MM/PBSA; molecular mechanics/Poisson Boltzmann surface area; MM/GBSA; molecular m
WIF1 can effectively co-regulate pro-apoptotic activity through the combination with DKK1
Keywords: WIF1; Wnt inhibitory factor-1; Dvl; disheveled; FRP; Frizzled-related protein; DKK1; Dickkopf-1; VEGF; vascular endothelial growth factor; bFGF; basic fibroblast growth factor; FITC; fluorescein isothiocyanate; PI; propidium iodide; p70S6K; p70 ribosomal
New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
Keywords: ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;
mTOR signaling in tumorigenesis
Keywords: mTOR; the mechanistic target of rapamycin or the mammalian target of rapamycin; PIKK; phosphoinositide 3-kinase related protein kinase; ATM; ataxia-telangiectasia mutated; ATR; ataxia-telangiectasia and rad3-related; DNAPK; DNA-dependent protein kinase; R
PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice
Keywords: Pancreatic Cancer; Signal Transduction; Cytoskeleton; Oncogene; ADM; acinar-to-ductal metaplasia; DAPI; 4â²,6-diamidino-2-phenylindole; EGFR; epidermal growth factor receptor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GEF; guanine nucleotide excha
The structural basis of action of vanadyl (VO2+) chelates in cells
Keywords: acac; acetylacetonate, as in bis(acetylacetonato)oxidovanadium(IV) or VO(acac)2; alx; allixin; ASP; acylation-stimulating protein; CHO; Chinese hamster ovary; ENDOR; electron nuclear double resonance; EGFR; epidermal growth factor receptor; EPR; electron
Crosstalk between secondary messengers, hormones and MAPK modules during abiotic stress signalling in plants
Keywords: ABA; abscisic acid; ACS; 1-aminocyclopropane-1-carboxylic acid synthases; ANP1; Arabidopsis NPK1-like protein kinase (MAP3K); CAT; catalase; CSD1/2; Cu/Zn superoxide dismutase; CTR1; constitutive triple response 1; EIN2; ethylene-insensitive 2; HsfA2; hea
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig
Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes
Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; BCS; bovine calf serum; C/EBPα; CCAAT element binding protein α; FABP4; fatty acid-binding protein 4; FACS; fluorescence-activated cell sorting; FAS; fatty acid synthase; FBS; fetal bovine serum; Hsp90; he
p53 regulates glucose metabolism by miR-34a
Keywords: p53; miR-34a; Glycolysis; HK; GPI; PDK1;
TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complex
Keywords: TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; CIN85; c-Cbl interacting protein of 85Â kDa; DR4/5; death receptor 4/5; TRAF4; TNF receptor-associated factor 4; GADD45; growth arrest and DNA damage induced gene-45; HSP27; heat shock protei
Two Pdk1 phosphorylation sites on the plant cell death suppressor Adi3 contribute to substrate phosphorylation
Keywords: Adi3; AvrPto-dependent Pto-interacting protein 3; Gal83; galactose-specific gene 83; MBP; maltose binding protein; Pdk1; 3-phosphoinositide dependent protein kinase 1; PCD; programmed cell death; SnRK1; Sucrose non-Fermenting-1-Related Protein Kinase 1; A
Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453
Keywords: PUFA; polyunsaturated fatty acid; RTK; receptor tyrosine kinase; FGFR; fibroblast growth factor receptor; IGFR; insulin-like growth factor receptor; PDK1; phosphoinositide-dependent kinase 1; mTOR; mammalian target of rapamycin; PDGF; platelet-derived gro