How well do aliskiren's purported mechanisms track its effects on cardiovascular and renal disorders?

► This review focuses on the effectiveness of aliskiren beyond the treatment of hypertension. ► Aliskiren might have cardiovascular and renoprotective effects. ► Aliskiren might regulate the function of RAAS, (pro)renin and Wnt/Frizzled signals. ► We discuss in this review the novel mechanistic insights of aliskiren in the signal network.