کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351712 | 1298078 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of c-Jun-N-terminal kinase in a rat model of intracerebral hemorrhage: The role of iron
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کلمات کلیدی
PBSpower of hydrogenFDAc-Jun-N-terminal kinasePaO2DFXPaCO2ECLi.p.kiloDaltonkDaDeferoxamineJnkIgGSDS–PAGE - SDS-PAGEadenosine triphosphatase - آدنوزین تری فسفاتازIron - آهنsodium dodecyl sulfate–polyacrylamide gel electrophoresis - الکتروفورز ژل دوده سولفات سدیم پلی آکریل آمیدimmunoglobulin G - ایمونوگلوبولین GATPase - ایتیپیایزها enhanced chemiluminescence - بهبود شیمیایی لومنintraperitoneal injection - تزریق داخل صفاقیintracerebral hemorrhage - خونریزی داخل مغزیCerebral hemorrhage - خونریزی مغزیFood and Drug Administration - سازمان غذا و داروCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریICH - منHolo-transferrin - هولوترنرین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Activation of c-Jun-N-terminal kinase in a rat model of intracerebral hemorrhage: The role of iron Activation of c-Jun-N-terminal kinase in a rat model of intracerebral hemorrhage: The role of iron](/preview/png/4351712.png)
چکیده انگلیسی
Iron accumulates in the brain and contributes to brain injury after intracerebral hemorrhage (ICH). The c-Jun-N-terminal kinase (JNK) signaling pathway mediates cell death after ischemic stroke, however, the involvement of JNK in ICH is not well known. This study investigated whether the JNK signaling pathway is activated by iron after ICH. Male Sprague-Dawley rats received an infusion of autologous whole blood (as a model of ICH) or ferrous iron into the right basal ganglia and control rats had an infusion of saline. Some ICH rats were treated with either deferoxamine (DFX), an iron chelator, or vehicle. Activation of JNK was measured by Western blot analysis and immunohistochemistry. Free iron in cerebrospinal fluid (CSF) and behavioral outcomes following ICH were also examined. We found that activated JNK in the brain were increased after ICH, and an intracerebral infusion of ferrous iron also upregulated brain activated JNK. Free iron accumulated in CSF and systemic administration of DFX after ICH reduces free iron contents in CSF, suppresses JNK activation and improves ICH-induced neurological deficits. Our results demonstrated that the JNK signaling pathway is activated after ICH and iron may contribute to this activation. DFX reduces free iron levels and attenuates activation of JNK suggesting iron chelation may be useful therapy for ICH patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 63, Issue 2, February 2009, Pages 100-105
Journal: Neuroscience Research - Volume 63, Issue 2, February 2009, Pages 100-105
نویسندگان
Shu Wan, Renya Zhan, Shusen Zheng, Ya Hua, Guohua Xi,