Altered expression of GABAa and GABAb receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus

The observed changes suggest substantial and cell specific rearrangement of GABA receptors. Lasting downregulation of subunits δ and α5 in granule cells and transient decreases in subunit α2 and β1-3 mRNA levels in cornu ammonis 3 pyramidal cells are suggestive of impaired GABAA receptor-mediated inhibition. Persistent upregulation of subunits β1-3 and γ2 of the GABAA receptor and of GABABR2 mRNA in granule cells, however, may result in activation of compensatory anticonvulsant mechanisms.