کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425858 | 1295895 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fos activation in hypothalamic neurons during cold or warm exposure: Projections to periaqueductal gray matter
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کلمات کلیدی
MPAPVHVMHMNPOVLHBSTPAGPEFBATDMHLPOCTBAHAPOADABFOSABC3,3′-diaminobenzidine - 3،3'-diaminobenzidineMPO - DFOPMd - PMDFos immunoreactivity - ایمونوئوراکتیو Fosbrown adipose tissue - بافت چربی قهوه ایThermoregulation - ترموستات یا دستگاه تنظیم حرارتAmbient temperature - دمای محیطDHA - دوکوساهگزائنوئیک اسیدFos-ir - فوزیPeriaqueductal gray matter - ماده خاکستری پرایاکوداکتAvidin-biotin complex - مجتمع آیدین بیوتینPreoptic area - منطقه PreopticLateral preoptic area - منطقه دایره ای جانبیzona incerta - منطقه نامشخصlateral hypothalamic area - منطقه هیپوتالاموس جانبیanterior hypothalamic area - منطقه هیپوتالاموس قدامیPosterior hypothalamic area - منطقه هیپوتالاموس پشتیperifornical area - منطقه پرایفنیکmedial preoptic area - منطقه پیشوپتیک مدیاdorsal hypothalamic area - منطقه ی هیپوتالاموس پشتیbed nucleus of the stria terminalis - هسته تخت ترمینال های استریParastrial nucleus - هسته عادیdorsomedial hypothalamic nucleus - هسته هیپوتالاموس dorsomedialVentromedial hypothalamic nucleus - هسته هیپوتالاموس Ventromedialparaventricular hypothalamic nucleus - هسته هیپوتالاموس پروژستیکDorsal premammillary nucleus - هسته پرمامیلری پشتیmedial preoptic nucleus - هسته پیشوپتیک مدیاmedian preoptic nucleus - هسته پیشوپتیک مدیاست
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The hypothalamus, especially the preoptic area, plays a crucial role in thermoregulation, and our previous studies showed that the periaqueductal gray matter is important for transmitting efferent signals to thermoregulatory effectors in rats. Neurons responsible for skin vasodilation are located in the lateral portion of the rostral periaqueductal gray matter, and neurons that mediate non-shivering thermogenesis are located in the ventrolateral part of the caudal periaqueductal gray matter. We investigated the distribution of neurons in the rat hypothalamus that are activated by exposure to neutral (26°C), warm (33°C), or cold (10°C) ambient temperature and project to the rostral periaqueductal gray matter or caudal periaqueductal gray matter, by using the immunohistochemical analysis of Fos and a retrograde tracer, cholera toxin-b. When cholera toxin-b was injected into the rostral periaqueductal gray matter, many double-labeled cells were observed in the median preoptic nucleus in warm-exposed rats, but few were seen in cold-exposed rats. On the other hand, when cholera toxin-b was injected into the caudal periaqueductal gray matter, many double-labeled cells were seen in a cell group extending from the dorsomedial nucleus through the dorsal hypothalamic area in cold-exposed rats but few were seen in warm-exposed rats. These results suggest that the rostral periaqueductal gray matter receives input from the median preoptic nucleus neurons activated by warm exposure, and the caudal periaqueductal gray matter receives input from neurons in the dorsomedial nucleus/dorsal hypothalamic area region activated by cold exposure. These efferent pathways provide a substrate for thermoregulatory skin vasomotor response and non-shivering thermogenesis, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 133, Issue 4, 2005, Pages 1039-1046
Journal: Neuroscience - Volume 133, Issue 4, 2005, Pages 1039-1046
نویسندگان
K. Yoshida, M. Konishi, K. Nagashima, C.B. Saper, K. Kanosue,