کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426593 | 1295927 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of feeding status on neuronal activity in the hypothalamus during lipopolysaccharide-induced anorexia in rats
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کلمات کلیدی
MCHCARTDAPIPOMCNPYDMHSSCCRHLPSβ-END4′,6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولβ-endorphin - β-آندورفینSTAT - آمارstandard saline citrate - استاندارد سدیم سیتراتinflammation - التهاب( توروم) interleukin - اینترلوکینAnorexia - بیاشتهاییanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceFasting - روزه داریCytokines - سیتوکین هاArc - قوسLeptin - لپتین lipopolysaccharide - لیپوپلی ساکاریدPVN - مالیات بر ارزش افزودهSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیNeuropeptides - نوروپپتیدهاSupraoptic nucleus - هسته Supraopticarcuate nucleus - هسته قوسparaventricular nucleus - هسته پروژسترویکcorticotropin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینmelanin-concentrating hormone - هورمون متمرکز کننده ملانینdorsomedial hypothalamus - هیپوتالاموس dorsomediallateral hypothalamus - هیپوتالاموس جانبیproopiomelanocortin - پروپیوملانوکورتینNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Fasting attenuates disease-associated anorexia, but the mechanisms underlying this effect are not well understood. In the present study, we investigated the extent to which a 48 h fast alters hypothalamic neuronal activity in response to the anorectic effects of lipopolysaccharide in rats. Male rats were fed ad libitum or fasted, and were injected with i.p. saline or lipopolysaccharide (250μg/kg). Immunohistochemistry for Fos protein was used to visualize neuronal activity in response to lipopolysaccharide within selected hypothalamic feeding regulatory nuclei. Additionally, food intake, body weight, plasma interleukin-1 and leptin levels, and the expression of mRNA for appetite-related neuropeptides (neuropeptide Y, proopiomelanocortin and cocaine-amphetamine-regulated transcript) were measured in a time-related manner. Our data show that the pattern of lipopolysaccharide-induced Fos expression was similar in most hypothalamic nuclei whatever the feeding status. However, we observed that fasting significantly reduced lipopolysaccharide-induced Fos expression in the paraventricular nucleus, in association with an attenuated lipopolysaccharide-induced anorexia and body weight loss. Moreover, lipopolysaccharide reduced fasting-induced Fos expression in the perifornical area of the lateral hypothalamus. Lipopolysaccharide-induced circulating levels of interleukin-1 were similar across feeding status. Finally, fasting, but not lipopolysaccharide, affected circulating level of leptin and appetite-related neuropeptides expression in the arcuate nucleus. Together, our data show that fasting modulates lipopolysaccharide-induced anorexia and body weight loss in association with neural changes in specific hypothalamic nuclei.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 134, Issue 3, 2005, Pages 933-946
Journal: Neuroscience - Volume 134, Issue 3, 2005, Pages 933-946
نویسندگان
L. Gautron, R. Mingam, A. Moranis, C. Combe, S. Layé,