کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426594 | 1295927 | 2005 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Central autonomic control of the bone marrow: Multisynaptic tract tracing by recombinant pseudorabies virus
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
SPNPAGIMLNTSBNSTCGRPKPBSBDLNPYOVLTβ-galASPPVHBDGGFPLPGiPRVDABorganum vasculosum of the lamina terminalis - ارگانواسکوئوزوم ترمینال لامیناImmunoreactivity - ایمنی فعالβ-galactosidase - بتا گالاکتوزیدازtyrosine hydroxylase - تیروزین هیدروکسیلازAutonomic nervous system - دستگاه عصبی خودمختار یا خودگردان یا اتونومdiaminobenzidine - دیامینو بنزیدینbrain stem - ساقه مغزintermediolateral cell column - ستون سلول میان سلولیSpinal cord - طناب نخاعیimmediate early - فورا زودترlocus coeruleus - لوکوس سیرولئوسSubstance P - ماده PPeriaqueductal gray matter - ماده خاکستری پرایاکوداکتCAN - می توانSympathetic innervation - ناباروری سمپاتیکSympathetic preganglionic neurons - نورونهای پیشگنگلیونی سمپاتیکlateral paragigantocellular nucleus - هسته paragigantocellular جانبیbed nucleus of the stria terminalis - هسته تخت ترمینال های استریnucleus of the solitary tract - هسته دستگاه انفرادیHypothalamic paraventricular nucleus - هسته پروبیالیک هیپوتالامیکHypothalamus - هیپوتالاموسplaque-forming unit - واحد پلاک سازیPseudorabies virus - ویروس Pseudorabiespotassium phosphate-buffered saline - پتاسیم فسفات بافر شورgreen fluorescent protein - پروتئین فلورسنت سبزpfu - پفوcalcitonin gene-related peptide - پپتید مرتبط با ژن کلسی تونینNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Bone marrow is the primary place of hematopoiesis, where the development, survival and release of multipotent stem cells, progenitors, precursors and mature cells are under continuous humoral and neural control. Dense network of nerve fibers, containing various neurotransmitters is found in the bone marrow, however, the central neuronal circuit that regulates the activities of the bone marrow through these fibers remained unexplored. Transsynaptically connected neurons were mapped by virus-based transneuronal tracing technique using two isogenic, genetically engineered pseudorabies viruses, Bartha-DupGreen and Ba-DupLac expressing green fluorescent protein and β-galactosidase, respectively. Bartha-DupGreen was injected into the femoral bone marrow of male rats and the progression of infection was followed 4-7 days post-inoculation. Virus-labeled cells were revealed in ganglia of the paravertebral chain and in the intermediolateral cell column of the lower thoracic spinal cord. Neurons were retrogradely labeled in the C1, A5, A7 catecholaminergic cell groups and several other nuclei of the ventrolateral and ventromedial medulla, the periaqueductal gray matter, the paraventricular and other hypothalamic nuclei, and in the insular and piriform cortex. Nerve transections and double-virus tracing from the bone marrow and the surrounding muscles were used to confirm the specific spreading of the virus. These results provide anatomical evidence for the CNS control of the bone marrow and identify putative brain areas, which are involved in autonomic regulation of the hematopoiesis, the release of progenitor cells, the blood supply and the immune cell function in the bone marrow.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 134, Issue 3, 2005, Pages 947-963
Journal: Neuroscience - Volume 134, Issue 3, 2005, Pages 947-963
نویسندگان
Á. Dénes, Z. Boldogkoi, G. Uhereczky, Á. Hornyák, M. Rusvai, M. Palkovits, K.J. Kovács,