کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9428980 | 1297022 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in the beta-endorphin plasma level after repeated treatment with acamprosate in rats selectively bred for high and low alcohol preference
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Changes in the beta-endorphin plasma level after repeated treatment with acamprosate in rats selectively bred for high and low alcohol preference Changes in the beta-endorphin plasma level after repeated treatment with acamprosate in rats selectively bred for high and low alcohol preference](/preview/png/9428980.png)
چکیده انگلیسی
The aim of this study was to evaluate the beta-endorphin (β-endorphin) plasma level in Warsaw Low Preferring (WLP) and Warsaw high-preferring (WHP) rats after repeated administration of acamprosate, one of most effective drug in the treatment of alcoholism. Treatment with acamprosate in dose 200 mg/kg, p.o. for 10 days induced an increase in plasma β-endorphin levels. A single injection of ethanol also results in the increase of β-endorphin level. Moreover, it was found that single injection of ethanol to WHP rats resulted in lower increase of plasma β-endorphin content in rats earlier treated with acamprosate. In WLP rats, repeated acamprosate treatment prevents the ethanol-induced increase in plasma β-endorphin level. It may be concluded that acamprosate modulates the endogenous opioid system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 388, Issue 1, 4 November 2005, Pages 45-48
Journal: Neuroscience Letters - Volume 388, Issue 1, 4 November 2005, Pages 45-48
نویسندگان
Jadwiga Zalewska-Kaszubska, Wojciech Äwiek, Wanda Dyr, Elżbieta Czarnecka,