کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9429 629 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Imaging the disruption of phospholipid monolayer by protein-coated nanoparticles using ordering transitions of liquid crystals
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Imaging the disruption of phospholipid monolayer by protein-coated nanoparticles using ordering transitions of liquid crystals
چکیده انگلیسی

We report an easily visualized liquid crystal (LC)-based system to study the molecular interactions between protein-coated gold nanoparticles (AuNPs) and supported phospholipid monolayer self-assembled at the aqueous-LC interface. Protein-coated AuNPs were found to disrupt the phospholipid monolayer and resulted in the orientational transitions of LCs that support the phospholipid layer. The disruption of the phospholipid monolayer depends on the type of protein (albumin, neutravidin, and fibrinogen) adsorbing onto nanoparticles. Furthermore, our results suggest that hydrophobic interaction plays a major role in the disruption of the phospholipid layer by protein-coated AuNPs. Results obtained from this study may offer new understanding in the potential cytotoxicity of nanomaterials, where the interaction between nanoparticles and cell membrane is an important step.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 30, Issue 5, February 2009, Pages 843–849
نویسندگان
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