کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429112 | 1297030 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Minocycline does not inhibit microglia proliferation or neuronal regeneration in the facial nucleus following crush injury
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Minocycline does not inhibit microglia proliferation or neuronal regeneration in the facial nucleus following crush injury Minocycline does not inhibit microglia proliferation or neuronal regeneration in the facial nucleus following crush injury](/preview/png/9429112.png)
چکیده انگلیسی
Minocycline is thought to be neuroprotective by inhibiting neuroinflammation (microglial activation) associated with neurodegenerative diseases. In this study we investigated the effect of minocycline specifically on microglial mitotic activity and neuronal regeneration within the facial nucleus following a nerve crush injury. Proliferation was measured by labeling the dividing microglia with 3H-thymidine and quantifying labeled cells throughout the facial nucleus on days 2, 3 and 4 post-axotomy. Regeneration patterns of the axotomized motoneurons were studied by labeling regenerating neurons with fluorogold at 7, 14 and 21 days post-axotomy. No significant difference was found between minocycline treated and control rats when comparing the 3H-thymidine labeled microglial cells or fluorogold labeled neurons at these post-injury time points. The findings show that microglia maintain the ability to become activated in vivo even in the presence of high levels of minocycline.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 385, Issue 3, 16 September 2005, Pages 220-223
Journal: Neuroscience Letters - Volume 385, Issue 3, 16 September 2005, Pages 220-223
نویسندگان
Sarah E. Fendrick, Kelly R. Miller, Wolfgang J. Streit,