کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9429274 1297036 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spatial navigation in the Morris water maze: working and long lasting reference memories
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Spatial navigation in the Morris water maze: working and long lasting reference memories
چکیده انگلیسی
Spatial navigation development in the Morris water maze (MWM) paradigm was studied in 70-day-old male Long-Evans hooded rats. During 5 consecutive days, rats' training consisted of a daily block of 10 trials. Escape latency was measured in each trial. Probe testing was performed every day immediately before and after the daily block of trials. In addition, a final probe was performed on Day 6. During the first 3 days of training, the escape latency became progressively shorter, showing an asymptotic trend on Days 4 and 5. Probe trials administered at the end of the first acquisition sessions showed clear preference for the target quadrant but this information was not recalled at probe trials given 24 h later. The memory trace retrieved after 24-h delay was formed only after 30 trials received over three sessions. The probe trial given at the end of an acquisition session tests the efficiency of the working memory whereas the 24 h delayed probe trial reflects better-consolidated spatial information corresponding to long lasting reference memory. It can be noted that the progressive shortening of escape latencies does not express closely the evolution of the rat's long lasting (consolidated) reference memory. This memory can be satisfactorily measured only by probe testing performed at an adequate delay after training. These considerations may be of some interest when interpreting the rat's performance in the MWM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 378, Issue 3, 22 April 2005, Pages 176-180
نویسندگان
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