کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429312 | 1297038 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Photoinducible and rhythmic ICER-CREM immunoreactivity in the rat suprachiasmatic nucleus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Several genes expressed in the suprachiasmatic nucleus (SCN) are induced by light and are candidate links in the photic entrainment pathway of the SCN's circadian clock. Since the cAMP response element binding protein (CREB) and CRE-mediated gene transcription in the SCN appears to be crucial for light-induced phase shifts of circadian rhythmicity, we analyzed the immunohistochemical expression of proteins encoded by the cAMP response element modulator (CREM) gene, including a repressor isoform (inducible cAMP early repressor [ICER]). ICER-CREM immunoreactivity was detected in cells of the ventrolateral subdivision of the rat SCN after light administration during the subjective night in constant darkness; but only late after light onset (at 240Â min), following earlier successive peaks of phosphorylated CREB protein (by 5Â min), c-fos mRNA (by 40Â min), per1 mRNA (by 55Â min), and c-Fos protein (by 60Â min). In constant darkness, there was a modest but significant endogenous rhythm of ICER-CREM immunoreactivity, with a two-fold difference between high levels at circadian time (CT) 10 and low levels at CT 22. Our data raise the possibility that ICER-CREM might be involved in downregulating the SCN expression of immediate-early and “clock” genes after their induction by phase-shifting light pulses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 385, Issue 1, 2 September 2005, Pages 87-91
Journal: Neuroscience Letters - Volume 385, Issue 1, 2 September 2005, Pages 87-91
نویسندگان
William J. Schwartz, Neil Aronin, Paolo Sassone-Corsi,