کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429331 | 1615202 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease](/preview/png/9429331.png)
چکیده انگلیسی
Excessive synchronisation of basal ganglia activity at frequencies <30Â Hz is a hallmark of the parkinsonian state, and may contribute to bradykinesia. Accordingly, we electrically stimulated chronically implanted subthalamic macroelectrodes in 10 Parkinson's disease patients, after overnight withdrawal of anti-parkinsonian medication. We compared the effects of stimulation at 0, 5, 10, 15, 20, 25, 30, and ca. 130Â Hz by measuring kinesia time (KT) in a tapping task. Although the effects of direct stimulation were small, frequency-response curves demonstrated local peaks at 5-10Â Hz and at 20-25Â Hz, superimposed upon an overall tendency for KT to reduce with increasing stimulation frequency. This is consistent with the hypothesis that spontaneous activities in these bands might promote bradykinesia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 382, Issues 1â2, 1â8 July 2005, Pages 5-9
Journal: Neuroscience Letters - Volume 382, Issues 1â2, 1â8 July 2005, Pages 5-9
نویسندگان
Noa Fogelson, Andrea A. Kühn, Paul Silberstein, Patricia Dowsey Limousin, Marwan Hariz, Thomas Trottenberg, Andreas Kupsch, Peter Brown,