کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429361 | 1615202 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The dynamics of hippocampal sensory gating during the development of morphine dependence and withdrawal in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The dynamics of hippocampal sensory gating during the development of morphine dependence and withdrawal in rats The dynamics of hippocampal sensory gating during the development of morphine dependence and withdrawal in rats](/preview/png/9429361.png)
چکیده انگلیسی
The effects of morphine on hippocampal sensory gating (N40) during the development of morphine dependence and withdrawal were investigated in the double click auditory evoked potential (EP) suppression paradigm. Rats were made dependent upon morphine hydrochloride by a series of injections (every 12Â h) over 6 days, followed by withdrawal after stopping morphine administration. Hippocampal gating was examined during the development of dependence and withdrawal. Moreover, the DA antagonist haloperidol was used to assess the contribution of dopamine to hippocampal gating induced by morphine. Our results showed that the morphine-treated rats exhibited significantly disrupted hippocampal gating during the development of morphine dependence and this disrupted gating was partially reversed by haloperidol pretreatment. In contrast, there was significantly enhanced hippocampal gating at the fifth and sixth days of withdrawal. The dynamics of hippocampal gating during the development of morphine dependence and withdrawal suggests the interaction between the hippocampus and opioids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 382, Issues 1â2, 1â8 July 2005, Pages 164-168
Journal: Neuroscience Letters - Volume 382, Issues 1â2, 1â8 July 2005, Pages 164-168
نویسندگان
Jiawei Zheng, Yan Yang, Shaohua Tian, Jin Chen, Fraser A.W. Wilson, Yuanye Ma,