کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429392 | 1297042 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of norepinephrine and nitric oxide in activities of rat arginine vasopressin neurons in response to immune challenge
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of norepinephrine and nitric oxide in activities of rat arginine vasopressin neurons in response to immune challenge The role of norepinephrine and nitric oxide in activities of rat arginine vasopressin neurons in response to immune challenge](/preview/png/9429392.png)
چکیده انگلیسی
To explore the potential role of norepinephrine (NE) and nitric oxide (NO) in activities of rat hypothalamus arginine vasopressin (AVP) neurons in response to immune challenge, we observed the effect of prazosin, an antagonist of α1-adrenergic receptor, and the specific nitric oxide synthase (NOS) inhibitor Nwnitro-l-arginine-methylester (l-NAME) on the Fos expression in AVP neurons induced by systemic lipopolysaccharide (LPS) using double immunohistochemistry. Intravenous (i.v.) injection of LPS induced Fos expression in AVP neurons mainly in the hypothalamus paraventricular nucleus (PVN) and in the supraoptic nucleus (SON). The percentage of Fos-positive AVP neurons was dose-dependent. Pretreatment with prazosin (5 mg/kg) effectively suppressed the Fos expression induced by LPS (5 μg/kg), whereas l-NAME (30 mg/kg) did not influence the Fos expression in the AVP neurons induced by LPS (0.25, 0.5, 1, 5 μg/kg). Our results suggest that the activation of central AVP neurons caused by systemic LPS may be mediated by NE through α1-adrenergic receptors, but could not be changed by NO.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 383, Issue 3, 5 August 2005, Pages 231-235
Journal: Neuroscience Letters - Volume 383, Issue 3, 5 August 2005, Pages 231-235
نویسندگان
Shuang Xu, Shiyu Guo, Xinhong Jiang, Teruyasu Umezawa, Tadashi Hisamitsu,