کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429466 | 1297044 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate](/preview/png/9429466.png)
چکیده انگلیسی
Acute intrastriatal administration of methylmalonic acid (MMA) induces convulsions through NMDA receptor-mediated mechanisms and increases production of end products of oxidative damage. Although it has been demonstrated that nitric oxide (NO) production increases with NMDA receptor stimulation and contributes to the oxidative damage observed in several neurodegenerative disorders, the role of NO in MMA-induced convulsions has not been investigated to date. In the present study we investigated the effects of the intrastriatal injection of NÏ-nitro-l-arginine methyl ester (l-NAME: 10â4 to 100 nmol/0.5 μl) on the convulsions and striatal protein carbonylation induced by the intrastriatal injection of MMA (4.5 μmol/1.5 μl). l-NAME (10â3 to 10â1 nmol) protected against MMA-induced convulsions and protein carbonylation ex vivo. These results suggest the involvement of NO in the convulsive behavior and protein carbonylation elicited by MMA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 376, Issue 2, 11 March 2005, Pages 116-120
Journal: Neuroscience Letters - Volume 376, Issue 2, 11 March 2005, Pages 116-120
نویسندگان
Luiz Fernando Freire Royes, Michele Rechia Fighera, Ana Flávia Furian, Mauro Schneider Oliveira, Natália Gindri Fiorenza, Jociane de Carvalho Myskiw, Roberto Frussa-Filho, Carlos Fernando Mello,