کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429472 | 1297045 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Age-related changes in microvillar cells of rat olfactory epithelium
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Age-related changes in microvillar cells of rat olfactory epithelium Age-related changes in microvillar cells of rat olfactory epithelium](/preview/png/9429472.png)
چکیده انگلیسی
The nature and function of microvillar cells (MVCs) of the mammalian olfactory epithelium (OE) are little understood. Previous studies have examined MVC morphology in the developing and mature OE, but not in the aged OE. The present study investigated the effect of aging on MVCs of the OE in male Sprague-Dawley rats using histological and immunohistochemical methods. OE of aged rats contained MVCs with marked hypertrophy and swollen end-feet, which reached the basement membrane. Such MVC features were not observed in the young OE. These MVC changes were more conspicuous in proximity to severely degenerated olfactory receptor neurons (ORNs) and supporting cells. The ratio of the number of MVCs to that of supporting cells increased with aging; however, MVCs in the aged OE were not proliferating cell nuclear antigen-immunoreactive. In addition, the total cell population was decreased in the aged OE. Thus, our results suggest that MVCs are non-neuronal and that they are more resistant to aging compared to ORNs and supporting cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 378, Issue 2, 18 April 2005, Pages 65-69
Journal: Neuroscience Letters - Volume 378, Issue 2, 18 April 2005, Pages 65-69
نویسندگان
Bum Sun Kwon, Min Kyu Kim, Woo Ho Kim, Jung-Soo Pyo, Young Hee Cheon, Choong Ik Cha, Seon Young Nam, Tai-Kyoung Baik, Byung Lan Lee,