کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429475 | 1297045 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Delayed therapy of experimental global cerebral ischemia with acetyl-l-carnitine in dogs
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Acetyl-l-carnitine (ALCAR), when administered immediately following restoration of spontaneous circulation (ROSC) from experimental cardiac arrest (CA) has previously been demonstrated to promote normalization of brain energy metabolism and neurologic recovery following 10Â min CA. In order to determine ultimate efficacy for this or other drugs, clinical trials must be performed in human subjects. In several human clinical trials, though, drug administration has been significantly delayed following resuscitation from CA. These experiments test the hypothesis that post-resuscitative delay in ALCAR administration will impair the ability of this drug to promote neurologic recovery. Neurological deficit scoring (23Â h) as well as frontal cortex lactate levels (2 and 24Â h) were compared following resuscitation from 10Â min CA in dogs receiving either ALCAR or drug vehicle 30Â min following ROSC. Dogs treated with ALCAR 30Â min following ROSC from 10Â min CA exhibited more normal cerebral cortex lactate levels than did vehicle control animals. There was no difference, however, in neurologic deficit scores between groups, with all animals demonstrating moderate to severe clinical neurologic impairment at 23Â h following ROSC. A 30-min delay in ALCAR administration following ROSC from 10Â min CA impairs the ability of this drug to promote neurologic recovery despite apparent normalization of brain lactate levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 378, Issue 2, 18 April 2005, Pages 82-87
Journal: Neuroscience Letters - Volume 378, Issue 2, 18 April 2005, Pages 82-87
نویسندگان
Robert E. Rosenthal, Yolanda E. Bogaert, Gary Fiskum,