کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429555 | 1297049 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Facilitation of respiratory rhythm by a μ-opioid agonist in newborn rat pons-medulla-spinal cord preparations
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
We investigated the effect of a μ-opioid agonist, DAGO, on the respiratory frequency of pons-medulla-spinal cord preparations from newborn rats. Bath application of a low concentration of DAGO (0.2 μM) facilitated respiratory rhythm in pons-medulla-spinal cord preparations, whereas it induced respiratory depression in medulla-spinal cord preparations (without pons). At a higher concentration (1.0 μM), at which the inspiratory burst generation in the medulla was strongly depressed, the respiratory rhythm in half of the pons-medulla-spinal cord preparations increased and then decreased, thus showing a biphasic response. In the other half of these preparations, only the facilitatory effect was observed. The burst rate of pre-inspiratory neurons in the rostral ventrolateral medulla was also facilitated by DAGO application. Such facilitation of the respiratory rhythm is probably due to disinhibition of a pontine inhibitory system. Our findings also suggest the existence of a pontine excitatory system, which is depressed by the pontine inhibitory system under control conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 375, Issue 1, 25 February 2005, Pages 19-22
Journal: Neuroscience Letters - Volume 375, Issue 1, 25 February 2005, Pages 19-22
نویسندگان
Ayaka Tanabe, Tomoko Fujii, Hiroshi Onimaru,