کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429672 | 1615203 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alterations in the substance P-induced anti-nociception in the central nervous system of rats after morphine tolerance
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Alterations in the substance P-induced anti-nociception in the central nervous system of rats after morphine tolerance Alterations in the substance P-induced anti-nociception in the central nervous system of rats after morphine tolerance](/preview/png/9429672.png)
چکیده انگلیسی
The present study investigated the alteration in intracerebroventricular administration of substance P-induced anti-nociception after morphine tolerance in rats. The nociceptive response latencies to noxious thermal and mechanical stimulation increased significantly after intracerebroventricular administration of SP in normal rats. The SP-induced anti-nociception decreased significantly in morphine-tolerant rats than that in opioid naïve rats. The results demonstrated that SP induced significant anti-nociceptive effects in the brain in normal rats, and the SP-induced anti-nociception was attenuated significantly in morphine-tolerant rats than that in opioid naïve rats, indicating an alteration in SP-induced anti-nociception in the brain after chronic morphine treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 381, Issues 1â2, 10â17 June 2005, Pages 47-50
Journal: Neuroscience Letters - Volume 381, Issues 1â2, 10â17 June 2005, Pages 47-50
نویسندگان
Xiao-Guo Dong, Long-Chuan Yu,