کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429683 | 1615203 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The GABA type A receptor α5 subunit gene is associated with bipolar I disorder
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Several genetic studies have revealed that bipolar disorders are linked with the chromosomal locus of 15q11-q13, where the γ-aminobutyric acid (GABA) receptor α5 subunit gene (GABRA5) locates. GABA is one of the major neurotransmitters that may be involved in the pathogenesis of bipolar disorder. Five polymorphisms in the GABRA5 gene, â754C > T in the promoter region, IVS1-21G > A, IVS2-26T > A, *302C > T in 3â²-UTR of exon 5, and a CA repeat polymorphism in the 3â² flanking region were examined in a Japanese population. IVS1-21G > A exhibited significant differences in the distribution of the genotype and allele frequency in bipolar I disorder patients but not in bipolar II disorder patients, compared with control subjects. The haplotype analysis showed that IVS1-21G > A/IVS2-26A > T was associated with bipolar I disorder, and the IVS1-21A/IVS2-26T haplotype was a negative risk factor for susceptibility to the disorders (odds ratio: 0.57, 95% confidence interval: 0.44-0.73). These results suggest that the GABRA5 gene may confer susceptibility to bipolar I disorder.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 381, Issues 1â2, 10â17 June 2005, Pages 108-113
Journal: Neuroscience Letters - Volume 381, Issues 1â2, 10â17 June 2005, Pages 108-113
نویسندگان
Kyohei Otani, Hiroshi Ujike, Yuji Tanaka, Yukitaka Morita, Takeshi Katsu, Akira Nomura, Naohiko Uchida, Takashi Hamamura, Yutaka Fujiwara, Shigetoshi Kuroda,