کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429861 | 1297064 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFR-α) following experimental intracerebral hemorrhage in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Ciliary neurotrophic factor (CNTF) is known as a neuro-survival factor in the developing and developed CNS, as well as in the CNS following injury. However, little is known about the expression of CNTF or that of its receptor (CNTFR-α) in cases of intracerebral hemorrhage (ICH). We investigated the temporal and spatial profiles of CNTF and CNTFR-α expression using a collagenase-induced ICH rat model. CNTF expression was up-regulated from the day following ICH induction and reached a peak level at 5 to 14 days, with increased expression observed in brain tissue surrounding the hematoma lesion and white matter structures in association with astroglial proliferation. Further, CNTFR-α was transiently expressed in the cerebral cortex surrounding the hematoma, with a peak at 5 days. Administration of exogenous CNTF into the lesion following initiation of ICH resulted in a prolonged expression of CNTFR-α on cortical neurons neighboring the hematoma. Our findings suggest differential regulation of CNTF and CNTFR-α, and the possibility of a therapeutic strategy using CNTF administration for ICH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 377, Issue 3, 4 April 2005, Pages 170-175
Journal: Neuroscience Letters - Volume 377, Issue 3, 4 April 2005, Pages 170-175
نویسندگان
Hiroshi Yokota, Masahide Yoshikawa, Hidehiro Hirabayashi, Hiroyuki Nakase, Ryunosuke Uranishi, Fumihiko Nishimura, Yuko Sugie, Shigeaki Ishizaka, Toshisuke Sakaki,