کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429867 | 1297064 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gqα subunit mediates receptor site-specific adaptation in the sugar taste receptor cell of the blowfly, Phormia regina
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Gqα subunit mediates receptor site-specific adaptation in the sugar taste receptor cell of the blowfly, Phormia regina Gqα subunit mediates receptor site-specific adaptation in the sugar taste receptor cell of the blowfly, Phormia regina](/preview/png/9429867.png)
چکیده انگلیسی
The gustatory system is essential for almost all animals. The recent identification of G protein-coupled receptor proteins (GPCRs) has progressed molecular biological studies of gustatory systems, although the signal transduction mechanisms have not yet been fully elucidated. In vision and olfactory receptor cells, Gq class G protein is known to be a major signal transducer. By functional blocking of intrinsic Gq with an anti-Gq/11α antibody, we investigated the roles of Gq in the sugar receptor cell of the blowfly, Phormia regina. Before and after introduction of the anti-Gq/11α antibody into the cell through the DOC-permeabilized cell membrane, we recorded the responses of the receptor cell to sucrose and d-fructose, which stimulate different receptor sites, respectively. The initial impulse frequency in response to either sucrose or d-fructose was not changed by antibody introduction, whereas the adaptation rate in sucrose stimulation, but not fructose stimulation, became slower after antibody introduction. These results indicate that: (1) Gq is a regulator of adaptation in the sugar receptor cell of Phormia, rather than a transducer, and (2) different adaptation mechanisms are promoted by stimulations with sucrose and d-fructose.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 377, Issue 3, 4 April 2005, Pages 200-205
Journal: Neuroscience Letters - Volume 377, Issue 3, 4 April 2005, Pages 200-205
نویسندگان
Keiji Seno, Kazuyo Fujikawa, Tadashi Nakamura, Mamiko Ozaki,