کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9434314 1298138 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in G proteins genes expression in rat lumbar spinal cord support the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Changes in G proteins genes expression in rat lumbar spinal cord support the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia
چکیده انگلیسی
Due to synchronous development of morphine tolerance and changes in expression of Gβ, it may be concluded that the development of tolerance to analgesic effect of morphine is partially mediated by increase in Gβ gene expression. The increase in Gαi/o genes expression produced by chronic pain may facilitate the opioid signaling pathway and compensate for morphine-induced tolerance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 53, Issue 3, November 2005, Pages 250-256
نویسندگان
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