کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9434315 | 1298138 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Depolarizing effect of GABA in horizontal cells of the rabbit retina
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Gamma-amino butyric acid (GABA) has been characterized as an inhibitory neurotransmitter acting through chloride mediated channels in the adult nervous system. Using gramicidin-perforated patch clamp recordings from horizontal cells dissociated from the retinas of adult rabbits, we found that GABA is able to induce cell depolarization. Ionic currents induced by GABA in dissociated horizontal cells showed a reversal potential close to â30Â mV. This value is more positive than the resting potential of these cells (ca. â70Â mV). Therefore, according to the Nernst equation, the intracellular chloride concentration in horizontal cells was estimated to be of 44Â mM. The depolarizing effect of GABA at the dendrites of horizontal cells may serve to shape the center-surround organization of the receptive fields in retinal cells, thereby securing the shape discrimination of visual input.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 53, Issue 3, November 2005, Pages 257-264
Journal: Neuroscience Research - Volume 53, Issue 3, November 2005, Pages 257-264
نویسندگان
Carolina Varela, Luis Rivera, Román Blanco, Pedro De la Villa,