کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9435102 | 1298535 | 2005 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The functional role of the subthalamic nucleus in cognitive and limbic circuits
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کلمات کلیدی
ADLMotor circuitDLPCDPCLFSlOFCsRTUPDRSGPiHFSSTNDRNMPFCMPTPSubstantia nigra pars reticulata6-HydroxydopamineQOLSNC6-OHDASNRCrtGPEQuality of life - کیفیت زندگی1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineVentral pallidum - pallidum درشتGlobus pallidus internus - pallidus بغض در گلو داخلیγ-amino butyric acid - γ-آمینو اسید بوتیریکParkinson disease - بیماری پارکینسونlow-frequency stimulation - تحریک با فرکانس پایینdeep brain stimulation - تحریک عمقی مغزhigh-frequency stimulation - تحریک فرکانس بالاsubstantia nigra - توده سیاهsubstantia nigra pars compacta - توده سیاه پارس متراکمBehavior - رفتارreaction time - زمان واکنشChoice reaction time - زمان واکنش انتخابSimple reaction time - زمان واکنش سادهLesions - ضایعاتActivities of daily living - فعالیت های روزمره زندگیlateral orbitofrontal cortex - قشر اوربیتوفرناتال جانبیmedial prefrontal cortex - قشر غده پروسترولdorsolateral prefrontal cortex - قشر پیشانی غدد درون رحمیPPN - مالیات بر ارزش افزودهLoc - محلunified Parkinson disease rating scale - مقیاس رتبه بندی بیماری پارکینس یکپارچهzona incerta - منطقه نامشخصentopeduncular nucleus - هسته entopeduncularPedunculopontine nucleus - هسته Pedunculopontinedorsal raphe nucleus - هسته رافهmediodorsal nucleus of the thalamus - هسته مدیودورال تالاموسSubthalamic nucleus - هسته ی زیرهالامیکHemiballismus - همبستگیanterior commissure - کمربند قدامیGABA - گاباGlobus pallidus - گوی رنگ پریده، گلوبوس پالیدوس
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The functional role of the subthalamic nucleus in cognitive and limbic circuits The functional role of the subthalamic nucleus in cognitive and limbic circuits](/preview/png/9435102.png)
چکیده انگلیسی
Once it was believed that the subthalamic nucleus (STN) was no more than a relay station serving as a “gate” for ascending basal ganglia-thalamocortical circuits. Nowadays, the STN is considered to be one of the main regulators of motor function related to the basal ganglia. The role of the STN in the regulation of associative and limbic functions related to the basal ganglia has generally received little attention. In the present review, the functional role of the STN in the control of cortico-basal ganglia-thalamocortical associative and limbic circuits is discussed. In the past 20 years the concepts about the functional role of the STN have changed dramatically: from being an inhibitory nucleus to a potent excitatory nucleus, and from being involved in hyperkinesias to hypokinesias. However, it has been demonstrated only recently, mainly by reports on the behavioral (side-) effects of STN deep brain stimulation (DBS), which is a popular surgical technique in the treatment of patients suffering from advanced Parkinson Disease (PD), that the STN is clinically involved in associative and limbic functions. These findings were confirmed by results from animal studies. Experimental studies applying STN DBS or STN lesions to investigate the neuronal mechanisms involved in these procedures found profound effects on cognitive and motivational parameters. The anatomical, electrophysiological and behavioral data presented in this review point towards a potent regulatory function of the STN in the processing of associative and limbic information towards cortical and subcortical regions. In conclusion, it can be stated that the STN has anatomically a central position within the basal ganglia thalamocortical associative and limbic circuits and is functionally a potent regulator of these pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 76, Issue 6, August 2005, Pages 393-413
Journal: Progress in Neurobiology - Volume 76, Issue 6, August 2005, Pages 393-413
نویسندگان
Yasin Temel, Arjan Blokland, Harry W.M. Steinbusch, Veerle Visser-Vandewalle,