کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9436552 | 1615690 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lateralization of the effects of the benzodiazepine drug oxazepam on medial olivocochlear system activity in humans
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
BZDCASOHCsTEOAEMOCmedial olivocochlear - mediv olivocochlearEvoked otoacoustic emissions - انتشارات otoacoustic موجب شدBenzodiazepines - بنزودیازپینهاContralateral acoustic stimulation - تحریک آکوستیک متعاقب جانبیOuter hair cells - سلول های موی بیرونیSOC - سیستم روی یک تراشهLeft–right asymmetry - عدم تقارن چپ و راستsuperior olivary complex - مجتمع عالی ایلواریLoc - محلCochlear Nucleus - هسته کچلرInferior colliculus - کولیکولوس پایین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lateralization of the effects of the benzodiazepine drug oxazepam on medial olivocochlear system activity in humans Lateralization of the effects of the benzodiazepine drug oxazepam on medial olivocochlear system activity in humans](/preview/png/9436552.png)
چکیده انگلیسی
Benzodiazepines (Bzd) are known to interact with GABAergic inhibitory neurotransmission. Previous research on their effect on human auditory efferent pathways - through evoked otoacoustic emissions suppression by contralateral acoustic stimulation (CAS) - indicated a decrease in medial olivocochlear (MOC) efferent system inhibitory activity, after oral intake of oxazepam - representative of the Bzd drug class. To date, this pharmacological effect was only assessed in the right ear. Since a leftward asymmetry of Bzd receptors localization in human auditory cortex has been described recently, we explored in this study the hypothesis of an asymmetrical action of Bzd on MOC efferent functioning. The results revealed a significant difference of Bzd effect probing the right ear versus the left ear, with CAS-induced suppression being less effective in the right than left ear after oxazepam intake. This finding raises the question of possible neurochemical left-right asymmetry in the descending auditory pathways. The potential localization of this asymmetry is discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 208, Issues 1â2, October 2005, Pages 101-106
Journal: Hearing Research - Volume 208, Issues 1â2, October 2005, Pages 101-106
نویسندگان
N. Morand-Villeneuve, E. Veuillet, X. Perrot, P. Lemoine, M.C. Gagnieu, P. Sebert, J.D. Durrant, L. Collet,