کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9436691 | 1615698 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inner ear histopathology in “nervous Pointer dogs” with severe hearing loss
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کلمات کلیدی
TBSSPLNHSBAERBSA - BSAbovine serum albumin - آلبومین سرم گاوHereditary - ارثیHearing loss - از دست دادن شنواییTris buffer saline - بیس بال Trispostnatal days - روزهای پس از تولدnormal horse serum - سرم طبیعی اسبSound pressure level - سطح فشار صوتDog - سگBrainstem auditory evoked potentials - گوش شنوایی مغزی موجب بروز پتانسیل ها می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inner ear histopathology in “nervous Pointer dogs” with severe hearing loss Inner ear histopathology in “nervous Pointer dogs” with severe hearing loss](/preview/png/9436691.png)
چکیده انگلیسی
In 82 day-old puppies (n = 2), severe lesions of the Corti's organ, meaning that it was replaced by a layer of unidentifiable cells, involved the lower middle and upper basal turns junction area, extending in the upper basal turn. Mild lesions of the Corti's organ, with both hair and supporting cells abnormalities, involved the lower middle turn and extended from the rest of upper basal turn into the lower basal turn. The outer hair cells (ohc) were more affected than the inner hair cell (ihc). The lesions extended towards the basal end of the cochlea in the 131 (n = 5) and 148 (n = 3) day-old puppies. Additionally, the number of spiral ganglion neurons was reduced in the 131 and 148 day-old puppies; it is earlier than observed in most other canine hereditary deafness. These lesions were interpreted as a degeneration of the neuroepithelial type. This possible animal model might provide information about progressive juvenile hereditary deafness and neuronal retrograde degeneration investigations in human.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 200, Issues 1â2, February 2005, Pages 51-62
Journal: Hearing Research - Volume 200, Issues 1â2, February 2005, Pages 51-62
نویسندگان
Angélique G. Coppens, Shana Gilbert-Gregory, Sheldon A. Steinberg, Claus Heizmann, Luc Poncelet,