کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
945365 925778 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emotion recognition impairment and apathy after subthalamic nucleus stimulation in Parkinson's disease have separate neural substrates
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Emotion recognition impairment and apathy after subthalamic nucleus stimulation in Parkinson's disease have separate neural substrates
چکیده انگلیسی

ObjectiveTo test the hypothesis that emotion recognition and apathy share the same functional circuit involving the subthalamic nucleus (STN).MethodsA consecutive series of 17 patients with advanced Parkinson's disease (PD) was assessed 3 months before (M − 3) and 3 months (M + 3) after STN deep brain stimulation (DBS). Mean (±S.D.) age at surgery was 56.9 (8.7) years. Mean disease duration at surgery was 11.8 (2.6) years. Apathy was measured using the Apathy Evaluation Scale (AES) at both M−3 and M3. Patients were also assessed using a computerised paradigm of facial emotion recognition [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto: Consulting Psychologist Press] before and after STN DBS. Prior to this, the Benton Facial Recognition Test was used to check that the ability to perceive faces was intact.ResultsApathy had significantly worsened at M3 (42.5 ± 8.9, p = 0.006) after STN-DBS, in relation to the preoperative assessment (37.2 ± 5.5). There was also a significant reduction in recognition percentages for facial expressions of fear (43.1% ± 22.9 vs. 61.6% ± 21.4, p = 0.022) and sadness (52.7% ± 19.1 vs. 67.6% ± 22.8, p = 0.031) after STN DBS. However, the postoperative worsening of apathy and emotion recognition impairment were not correlated.ConclusionsOur results confirm that the STN is involved in both the apathy and emotion recognition networks. However, the absence of any correlation between apathy and emotion recognition impairment suggests that the worsening of apathy following surgery could not be explained by a lack of facial emotion recognition and that its behavioural and cognitive components should therefore also be taken into consideration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 46, Issue 11, September 2008, Pages 2796–2801
نویسندگان
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