کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9454781 | 1308556 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow by gavage administration
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
In this study, a synthetic pyrethroid insecticide, lambda-cyhalothrin (LCT), was administered to adult female albino rats (Wistar rats) by gavage dose of 6.12, 3.06, 0.8Â mg/kg b.w. repeated for 13 days at 48Â h intervals. The cytotoxic and genotoxic effects of LCT were investigated in bone marrow cells, using the structural chromosomal aberration (SCA) and micronucleus (MN) test systems. Mitomycin C (MMC) was also used as positive control (2Â mg/kg b.w.). All the doses of LCT increased the number of SCAs and the frequency of micronucleated erythrocytes, with respect to the control group. Only the highest dose of LCT significantly increased the MN frequency compared with control (P<0.01). It was also observed that LCT caused a significant decrease in the number of polychromatic erythrocytes compared with controls (p<0.001). These observations indicate the in vivo suspectibility of mammals to the genetic toxicity and cytotoxicity potential of LCT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 61, Issue 1, May 2005, Pages 128-133
Journal: Ecotoxicology and Environmental Safety - Volume 61, Issue 1, May 2005, Pages 128-133
نویسندگان
Ayla Ãelik, Birgül Mazmanci, Yusuf Ãamlica, Ãlkü ÃömelekoÄlu, Ali AÅkin,