کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9454850 1308562 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of sister chromatid exchange and chromosomal aberration frequencies in peripheral blood lymphocytes of gasoline station attendants
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Evaluation of sister chromatid exchange and chromosomal aberration frequencies in peripheral blood lymphocytes of gasoline station attendants
چکیده انگلیسی
Petroleum derivatives constitute a complex mixture of chemicals which contain well-known genotoxicants, such as benzene. Thus, chronic occupational exposure to such derivatives may be considered to possess genotoxic risk. In the present study, frequencies of sister chromatid exchange (SCE); aberrant cells, including numerical and structural chromosomal aberrations; and chromosome aberrations were investigated in peripheral blood lymphocytes from 30 exposed workers (15 smokers and 15 nonsmokers) and 30 controls (15 smokers and 15 nonsmokers). The exposed subjects were employed at 12 different petrol pumping stations in the city of Mersin, Turkey. Urinary phenol levels of exposed workers were found to be significantly higher than those of control subjects. Benzene exposure and cigarette smoking decrease the replication index and mitotic index. There is an interaction between benzene exposure and cigarette smoking for replication index and mitotic index. There is no interaction between cigarette smoking and benzene exposure for chromosomal aberrations. The results indicate that there are significant differences in SCE values in the exposed workers compared to the control individuals (P<0.01), but there is no difference between smokers and nonsmokers for SCE frequency (P>0.05). SCE frequency is higher in smokers than in nonsmokers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 60, Issue 1, January 2005, Pages 106-112
نویسندگان
, ,