کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9464564 | 1314472 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens](/preview/png/9464564.png)
چکیده انگلیسی
Ultraviolet (UV) sunscreen products are popular because of concerns about UV radiation and skin cancer. Unfortunately, some of these products contain agents with estrogenic activity. We used an ovariectomized rat uterotrophic assay to measure the estrogenic activities of 2,4-dihydroxybenzophenone (2,4-DHBP), 2,2â²,4,4â²-tetrahydroxybenzophenone (2,2â²,4,4â²-THBP), and 4-hydroxybenzoic acid isobutyl ester (isobutyl-paraben), which are agents in UV sunscreens, and ethynyl estradiol (EE) and bisphenol A (BPA), which are positive controls. All chemicals increased rat uterine weights. The 10% effective doses (ED10, mg/kg/day) of EE, BPA, 2,4-DHBP, 2,2â²,4,4â²-THBP, and isobutyl-paraben, as determined by Hill equation analysis, where 5E-5, 41.1, 544.6, 33.0, and 230.9, respectively, and their relative potencies against EE were about 1/800,000, 1/10,000,000, 1/600,000, and 1/4,000,000, respectively. Our findings indicated that UV screens contain weak estrogenic compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 98, Issue 1, May 2005, Pages 40-45
Journal: Environmental Research - Volume 98, Issue 1, May 2005, Pages 40-45
نویسندگان
Tomoko Koda, Toyoshi Umezu, Ryo Kamata, Kaori Morohoshi, Toshiko Ohta, Masatoshi Morita,