کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
950110 | 926806 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan](/preview/png/950110.png)
ObjectiveThree job stress models/concepts (the job demands–control [DC] model, the effort–reward imbalance [ERI] model, and organizational justice) have been linked to coronary heart disease (CHD) at work. In recent years, oxidative DNA damage has been identified as a new risk factor for CHD. However, evidence for the association between these job stressors and oxidative DNA damage is limited. The present cross-sectional study investigated the association between these job stress models/concepts and oxidative DNA damage as a possible mediator of the adverse health effects of job stress.MethodsA total of 166 male and 51 female workers of a manufacturing factory in Japan were surveyed using a mailed questionnaire regarding job stressors and demographic, occupational, and lifestyle variables. Urinary concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, were also measured.ResultsIn male subjects, the urinary concentrations of 8-OHdG were significantly higher among the group with lower interactional justice, one of the two components of organizational justice; however, no association was observed with the DC model or the ERI model. In female subjects, high job demands/control ratio was significantly and positively associated with the urinary concentrations of 8-OHdG.ConclusionInteractional justice among male workers and the DC model-based strain among female workers may be associated with increased urinary concentrations of 8-OHdG which possibly reflects oxidative DNA damage.
Journal: Journal of Psychosomatic Research - Volume 66, Issue 4, April 2009, Pages 329–334