کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
95099 160414 2016 7 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Effects of intravenous infusion of glycerol on blood parameters and urinary glycerol concentrations
ترجمه فارسی عنوان
اثرات انفوزیون داخل وریدی از گلیسرول بر پارامترهای خون و غلظت گلیسرول ادراری
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• The intravenous infusion of glycerol alters doping-related blood markers.
• Glycerol itself has only a limited effect on the expansion of plasma.
• The infusion of glycerol can be largely detected using urine analysis.

In sports, the oral intake and intravenous administration of glycerol as a potential masking agent have been prohibited. The effect of glycerol on blood parameters was investigated by comparing the intravenous administration of glycerol (20 g/200 mL) with that of an electrolyte (8 g glucose/200 mL) as a comparator (n = 7, fixed-dose-rate i.v. infusion, 200 mL in 1 h). This study was also designed to evaluate whether the urinary concentrations reached the positivity threshold after the intravenous infusion of glycerol. Significant decreases of the haemoglobin (HGB, g/dL), haematocrit (HCT, %) and OFF-h Score (OFF-score) values were observed after the infusion of glycerol (P < 0.05 at 1–6 h). The differences in the HGB, HCT and OFF-score between pre- and post-administration were −0.49 ± 0.23 g/dL (2 h), −1.54 ± 0.73% (2 h) and −3.89 ± 3.66 (2 h), respectively. Glycerol infusion significantly increased the plasma volume by 12.1% (1 h), 6.3% (2 h) and 5.7% (3 h) compared with the initial values. The infusion of the comparator also increased the plasma volume by 9.6% (1 h), 5.8% (2 h) and 4.9% (3 h) compared with the values before infusion. There were no significant differences in the change of the plasma volume between the intravenous infusions of glycerol and the glucose-based electrolyte (as the comparator) (P ≥ 0.05). This finding might indicate that glycerol itself only exhibited limited effects on the expansion of plasma. After administration of glycerol, the urinary glycerol concentrations increased from 0.0013 ± 0.0004 mg/mL to 6.86 ± 2.86 mg/mL at 1 h and 6.45 ± 3.08 mg/mL at 2 h. The intravenous infusion of glycerol can most likely be detected using the current urine analysis; however, the dependence of the concentration of urinary glycerol on the urine volume should be considered.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 262, May 2016, Pages 121–127
نویسندگان
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