کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
95137 160415 2016 7 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleukin (IL)-8 immunoreactivity of injured axons and surrounding oligodendrocytes in traumatic head injury
ترجمه فارسی عنوان
ایمونوراکتیویتی اینترلوکین (IL) -8 آکسون های مجروح و الیگودندروسیت اطراف آن در ضربه به سر پس از سانحه
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
سفارش ترجمه تخصصی
با تضمین قیمت و کیفیت
خدمات تولید محتوا

این مقاله ISI می تواند منبع ارزشمندی برای تولید محتوا باشد.

  • تولید محتوا برای سایت و وبلاگ
  • تولید محتوا برای کتاب
  • تولید محتوا برای نشریات و روزنامه ها
  • و...

پایگاه «دانشیاری» آمادگی دارد با همکاری مجموعه «شهر محتوا» با استفاده از این مقاله علمی، برای شما به زبان فارسی، تولید محتوا نماید.

سفارش تولید محتوا
با 10 درصد تخفیف ویژه دانشیاری
کلمات کلیدی
آسیب آکسون آسیب زا؛ پروتئین پیش ساز بتا آمیلوئید (AβPP)؛ اینترلوکین (IL) -8؛ میلین سازی مجدد؛ ایمونوهیستوشیمی؛ تشخیص مرگ
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• We examined IL-8 immunoreactivity in the corpus callosum of deceased patients with traumatic brain injury.
• IL-8 immunoreactivity was detected in 9 of the 44 cases of traumatic brain injury.
• The survival time after traumatic brain injury of IL-8 immunoreactive cases was 3–24 days.
• IL-8 was also detected in oligodendrocytes surrounding the injured axons.

Interleukin (IL)-8 has been suggested to be a positive regulator of myelination in the central nervous system, in addition to its principal role as a chemokine for neutrophils. Immunostaining for beta-amyloid precursor protein (AβPP) is an effective tool for detecting traumatic axonal injury, although AβPP immunoreactivity can also indicate axonal injury due to hypoxic causes. In this study, we examined IL-8 and AβPP immunoreactivity in sections of corpus callosum obtained from deceased patients with blunt head injury and from equivalent control tissue. AβPP immunoreactivity was detected in injured axons, such as axonal bulbs and varicose axons, in 24 of 44 head injury cases. These AβPP immunoreactive cases had survived for more than 3 h. The AβPP immunostaining pattern can be classified into two types: traumatic (Pattern 1) and non-traumatic (Pattern 2) axonal injuries, which we described previously [Hayashi et al. Int. J. Legal Med. 129 (2015) 1085–1090]. Three of 44 control cases also showed AβPP immunoreactive injured axons as Pattern 2. In contrast, IL-8 immunoreactivity was detected in 7 AβPP immunoreactive and in 2 non-AβPP immunoreactive head injury cases, but was not detected in any of the 44 control cases, including the 3 AβPP immunoreactive control cases. The IL-8 immunoreactive cases had survived from 3 to 24 days, whereas those cases who survived less than 3 days (n = 29) and who survived 90 days (n = 1) were not IL-8 immunoreactive. Moreover, IL-8 was detected as Pattern 1 axons only. In addition, double immunofluorescence analysis showed that IL-8 is expressed by oligodendrocytes surrounding injured axons. In conclusion, our results suggest that immunohistochemical detection of IL-8 may be useful as a complementary diagnostic marker of traumatic axonal injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 263, June 2016, Pages 48–54
نویسندگان
,,,,,
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
سفارش ترجمه تخصصی
با تضمین قیمت و کیفیت