کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
95138 160415 2016 12 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
The synthesis and investigation of impurities found in Clandestine Laboratories: Baeyer–Villiger Route Part I; Synthesis of P2P from benzaldehyde and methyl ethyl ketone
ترجمه فارسی عنوان
سنتز و بررسی ناخالصی های موجود در آزمایشگاه های مخفی ها:مسیر Baeyer - Villiger ، بخش اول؛ سنتز P2P از بنزآلدهید و متیل اتیل کتون
کلمات کلیدی
واکنش Baeyer-Villiger؛ سنتز مخفی؛ مت آمفتامین. P2P
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Benzaldehyde and methyl ethyl ketone can be converted into methamphetamine in four steps.
• Baeyer–Villiger reaction is key in the production of P2P.
• Potential route specific impurities have been identified, independently synthesised and characterised.

The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple “fingerprint” profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK); a Baeyer–Villiger reaction; and ester hydrolysis. We have identified and selectively synthesised several impurities that may be used as route specific markers for this series of synthetic steps. Specifically these impurities are 3-methyl-4-phenyl-3-buten-2-one 3, 2-methyl-1,5-diphenylpenta-1,4-diene-3-one 9, 2-(methylamino)-3-methyl-4-phenyl-3-butene 16, 2-(Methylamino)-3-methyl-4-phenylbutane 17, and 1-(methylamino)-2-methyl-1,5-diphenylpenta-4-ene-3-one 22.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 263, June 2016, Pages 55–66
نویسندگان
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