کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
95336 160427 2015 8 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Evaluation of postmortem drug concentrations in cerebrospinal fluid compared with blood and pericardial fluid
ترجمه فارسی عنوان
بررسی غلظت داروهای پس از مرگ در مایع مغزی نخاعی در مقایسه با مایع خون و پریکارد
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Several drugs showed significant correlation between cerebrospinal fluid and blood or pericardial fluid levels.
• Cerebrospinal fluid in forensic toxicology as an alternative to blood.
• Routine investigation can contribute to assessment in individual cases.

In forensic toxicology, body fluids are important materials not only as alternatives to blood but also for investigation of postmortem drug redistributions and pharmaco-/toxicokinetic analysis; however, there are limited data on postmortem drug distributions in cerebrospinal fluid (CSF). The present study reviewed toxicological data of autopsy cases (n = 103), in which drugs were detected in CSF using gas chromatography/mass spectrometry (GC/MS), to investigate drug concentrations in CSF, compared with blood and pericardial fluid (PCF) concentrations. Oral/injected amphetamines (n = 23) showed similar CSF and blood/PCF concentrations with partly lower CSF concentrations (about ×0.5–1.1). CSF concentrations of the venous anesthetic midazolam (n = 7) were lower with poor correlations. Oral caffeine (n = 15), acetaminophen (n = 7), chlorpheniramine (n = 6), dihydrocodeine (n = 6), and phenobarbital (n = 21) showed equivalent to lower CSF concentrations (about ×0.2–1.2), compared with blood and PCF concentrations; however, CSF phenobarbital concentrations were high in a fatal intoxication case. CSF concentrations of phenothiazine derivatives (n = 29) were markedly lower (about ×0.1) than blood/PCF concentrations. The distribution of the local anesthetic lidocaine used in critical medical care (n = 49) markedly varied by case. These findings suggest that CSF is useful in routine forensic toxicology as an alternative to blood as well as for investigating pharmaco-/toxicokinetics and postmortem redistributions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 254, September 2015, Pages 118–125
نویسندگان
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