کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
95425 160429 2015 7 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
The harmful chemistry behind krokodil (desomorphine) synthesis and mechanisms of toxicity
ترجمه فارسی عنوان
شیمی مضر سنتز کروکودیل (دزومورفین) و مکانیسم سمیت
کلمات کلیدی
اپیوئیدها، دزومورفین، سنتز کروکودیل، افرادی که مواد مخدر مصرف می کنند علائم و نشانه ها
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• “Krokodil” is the street name for a cheap substitute for heroin.
• Desomorphine is the semi-synthetic opioid claimed to be the main active component.
• Codeine tablets, alkalis, iodine and red phosphorus are the main raw materials.
• Chemical content analysis of krokodil should help to explain toxic-related effects.

“Krokodil” is the street name for the homemade injectable mixture that has been used as a cheap substitute for heroin. Its use begun in Russia and Ukraine and nowadays is being spread over several other countries. Desomorphine is the semi-synthetic opioid claimed to be the main component of krokodil and considered to be responsible for its psychoactive characteristics. The starting materials for desomorphine synthesis are codeine tablets, alkali solutions, organic solvent, acidified water, iodine and red phosphorus, all of which are easily available in retail outlets, such as supermarkets, drugstores, etc. The resulting product is a light brown liquid that is called krokodil. People who inject krokodil present a great variety of serious signs and symptoms, including thrombophlebitis, ulcerations, gangrene, and necrosis, quickly evolving to limb amputation and death. These effects are thought to result from the toxic components produced as byproducts during the homemade drug synthesis.In this work, we reviewed several aspects of krokodil use, including its epidemiology, pharmacology and the chemical properties of the main active ingredient (desomorphine). To enhance our understanding of the clinical and toxic effects and to support the implementation of harm reduction measures, we also describe the “bathtub chemistry” of krokodil and the content of the final solution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 249, April 2015, Pages 207–213
نویسندگان
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